Hepatitis B-associated hepatocellular carcinoma in a young Haitian man: a review of screening guidelines.

MedStar author(s):
Citation: BMJ Case Reports. 12(10), 2019 Oct 10.PMID: 31604717Institution: MedStar Washington Hospital CenterDepartment: Medicine/Internal MedicineForm of publication: Journal ArticleMedline article type(s): Journal ArticleSubject headings: *Carcinoma, Hepatocellular/vi [Virology] | *Hepatitis B, Chronic/co [Complications] | *Liver Neoplasms/vi [Virology] | Adult | Antineoplastic Agents/tu [Therapeutic Use] | Carcinoma, Hepatocellular/dg [Diagnostic Imaging] | Carcinoma, Hepatocellular/dt [Drug Therapy] | Deoxycytidine/aa [Analogs & Derivatives] | Deoxycytidine/tu [Therapeutic Use] | Diagnosis, Differential | Fatal Outcome | Haiti | Hepatitis B, Chronic/di [Diagnosis] | Humans | Liver Neoplasms/dg [Diagnostic Imaging] | Liver Neoplasms/dt [Drug Therapy] | Male | Mass Screening | Oxaliplatin/tu [Therapeutic Use] | Practice Guidelines as Topic | Sorafenib/tu [Therapeutic Use] | Tomography, X-Ray ComputedYear: 2019ISSN:
  • 1757-790X
Name of journal: BMJ case reportsAbstract: Hepatocellular carcinoma (HCC) is a terminal, yet preventable, outcome of untreated infection with hepatitis B virus (HBV). HBV is endemic in many areas of Latin America and the Caribbean, including Haiti. Haitians have the highest incidence of liver cancer among Caribbean immigrants. Unfortunately, many of these patients are not screened, despite current guidelines. As HBV is treatable, screening of high-risk populations is crucial to early intervention and prevention of poor outcomes. We highlight the case of a young Haitian male immigrant who presented with unintentional weight loss and epigastric pain and found to have HCC associated with HBV. Despite chemotherapy, the patient died 15 months after diagnosis. Increased awareness of HBV among patients from high-incidence countries may result in early recognition of this disease and reduced morbidity and mortality from devastating complications. Copyright (c) BMJ Publishing Group Limited 2019. No commercial re-use. See rights and permissions. Published by BMJ.All authors: Nazari M, Rosenblum JS, Trumbo SFiscal year: FY2020Digital Object Identifier: Date added to catalog: 2019-11-05
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Journal Article MedStar Authors Catalog Article 31604717 Available 31604717

Hepatocellular carcinoma (HCC) is a terminal, yet preventable, outcome of untreated infection with hepatitis B virus (HBV). HBV is endemic in many areas of Latin America and the Caribbean, including Haiti. Haitians have the highest incidence of liver cancer among Caribbean immigrants. Unfortunately, many of these patients are not screened, despite current guidelines. As HBV is treatable, screening of high-risk populations is crucial to early intervention and prevention of poor outcomes. We highlight the case of a young Haitian male immigrant who presented with unintentional weight loss and epigastric pain and found to have HCC associated with HBV. Despite chemotherapy, the patient died 15 months after diagnosis. Increased awareness of HBV among patients from high-incidence countries may result in early recognition of this disease and reduced morbidity and mortality from devastating complications. Copyright (c) BMJ Publishing Group Limited 2019. No commercial re-use. See rights and permissions. Published by BMJ.

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