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Single-dose T3 administration: kinetics and effects on biochemical and physiological parameters.

by Jonklaas, Jacqueline; Burman, Kenneth D; Wang, Hong.
Citation: Therapeutic Drug Monitoring. 37(1):110-8, 2015 Feb..Journal: Therapeutic drug monitoring.ISSN: 0163-4356.Full author list: Jonklaas J; Burman KD; Wang H; Latham KR.UI/PMID: 24977379.Subject(s): Adolescent | Adult | Body Temperature/de [Drug Effects] | Body Weight/de [Drug Effects] | Female | Half-Life | Heart Rate/de [Drug Effects] | Humans | Male | Thyrotropin/bl [Blood] | Thyroxine/bl [Blood] | *Triiodothyronine/pk [Pharmacokinetics] | *Triiodothyronine/pd [Pharmacology] | Young AdultInstitution(s): MedStar Washington Hospital Center | MedStar Health Research InstituteDepartment(s): Medicine/EndocrinologyActivity type: Journal Article.Medline article type(s): Clinical Trial, Phase I | Journal Article | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov'tOnline resources: Click here to access online Digital Object Identifier: (Click here) Abbreviated citation: Ther Drug Monit. 37(1):110-8, 2015 Feb.Local Holdings: Available online from MWHC library: 1997 - present.Abstract: BACKGROUND: As changes in thyroid stimulating hormone (TSH), thyroid hormones, and vital signs after administration of a single dose of liothyronine have typically only been documented for 24 hours, we documented these parameters more than 96 hours.Abstract: METHODS: Blood samples were obtained for 4 days after administration of 50-mcg liothyronine to 12 healthy euthyroid participants. Concentrations of total and free triiodothyronine, free and total thyroxine, and TSH were measured. Vital signs were documented.Abstract: RESULTS: Triiodothyronine concentrations peaked at 2.5 hours after liothyronine administration. Heart rate (HR) increased by 5 hours after liothyronine administration, subsequently reaching a value higher than baseline (P = 0.009). Suppression of TSH concentrations began at 2 hours. The nadir TSH value at 12 hours was significantly different from baseline (P < 0.001) and remained lower than the baseline value for 2-3 days.Abstract: CONCLUSIONS: A single dose of liothyronine has both short-term and long-term effects. There is clearly a different lag time between the serum concentrations of triiodothyronine and its effects on the heart and pituitary, respectively. The increase in serum triiodothyronine concentration occurred within hours and was then followed by an increase in HR. The increased HR was transient and was followed by a reduction in TSH concentration. The suppression of TSH was delayed but was more sustained. Thus, sustained TSH reduction beyond 24 hours was achieved by a single dose of liothyronine that produced only brief increases in serum triiodothyronine levels and transient increases in HR.

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