Outcomes of Split-thickness Skin Grafting for Foot and Ankle Wounds in Patients With Peripheral Arterial Disease.

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Citation: Wounds-A Compendium of Clinical Research & Practice. 31(11):272-278, 2019 Nov.PMID: 31730509Institution: MedStar Health Research Institute | MedStar Washington Hospital CenterDepartment: Surgery/Plastic Surgery | Surgery/Podiatric Surgery | Surgery/Vascular SurgeryForm of publication: Journal ArticleMedline article type(s): Journal ArticleSubject headings: *Ankle/pa [Pathology] | *Foot/pa [Pathology] | *Ischemia/pp [Physiopathology] | *Peripheral Arterial Disease/pp [Physiopathology] | *Reconstructive Surgical Procedures/mt [Methods] | *Skin Transplantation/mt [Methods] | *Wound Healing/ph [Physiology] | Aged | Angiography | Angioplasty, Balloon | Ankle/bs [Blood Supply] | Debridement/mt [Methods] | Endovascular Procedures/mt [Methods] | Female | Foot/bs [Blood Supply] | Graft Survival/ph [Physiology] | Humans | Ischemia/su [Surgery] | Male | Middle Aged | Peripheral Arterial Disease/co [Complications] | Peripheral Arterial Disease/su [Surgery] | Retrospective Studies | Treatment OutcomeYear: 2019ISSN:
  • 1044-7946
Name of journal: Wounds : a compendium of clinical research and practiceAbstract: CONCLUSIONS: These results suggest the importance of arterial-arterial connections such as the pedal arch to the healing potential of foot and ankle wounds after STSG in this high-risk patient population.INTRODUCTION: Tissue ischemia resulting from arterial insufficiency is a major factor affecting lower extremity wound healing in patients with peripheral arterial disease (PAD). Accelerated wound closure with split-thickness skin grafting (STSG) provides a durable barrier to infection and can prevent limb loss. Published STSG outcomes data are minimal in the post endovascular intervention population.MATERIALS AND METHODS: Patients with PAD and wounds of the foot and ankle who underwent STSG between January 2014 and December 2016 were retrospectively reviewed. All patients received angiographic evaluation and endovascular or open revascularization where necessary. Effects of extremity revascularizations, STSG percent take, and amputation rate were evaluated.OBJECTIVE: In this study, the authors examine factors predictive of STSG healing in patients with PAD following vascular intervention, including the effect of non-inline flow via arterial-arterial and non-arterial collateralization.RESULTS: Thirty-five patients with 47 wounds underwent STSG. There were 21 men and 14 women with a mean age of 64 +/- 13 years. Revascularization was required in 23 patients (25 extremities) before STSG, with balloon angioplasty for tibial artery lesions as the most common revascularization. Patent pedal arch was present in 8 patients; 35 patients had an absent or incomplete pedal arch. Patients with a fully patent pedal arch healed at a significantly higher rate than those with an absent or incomplete pedal arch at 1 month (62.5% vs. 17.1%, P < .05). At 90-day follow-up, 9 of 35 (25.7%) patients with 9 of 47 (19.1%) wounds were lost to follow-up, leaving 18 of 38 (47.37%) wounds healed and 20 (52.63%) still open. Ultimately, 36 of 47 (76.60%) wounds healed and 6 major amputations in 6 patients were required at a mean 502 +/- 342 days follow-up.All authors: Akbari CM, Attinger CE, Evans KK, Janhofer DE, Kim PJ, Naz I, Penzler MM, Steinberg JS, Tefera EA, Walters ETOriginally published: Wounds-A Compendium of Clinical Research & Practice. 31(11):272-278, 2019 Nov.Fiscal year: FY2020Date added to catalog: 2019-12-04
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Journal Article MedStar Authors Catalog Article 31730509 Available 31730509

CONCLUSIONS: These results suggest the importance of arterial-arterial connections such as the pedal arch to the healing potential of foot and ankle wounds after STSG in this high-risk patient population.

INTRODUCTION: Tissue ischemia resulting from arterial insufficiency is a major factor affecting lower extremity wound healing in patients with peripheral arterial disease (PAD). Accelerated wound closure with split-thickness skin grafting (STSG) provides a durable barrier to infection and can prevent limb loss. Published STSG outcomes data are minimal in the post endovascular intervention population.

MATERIALS AND METHODS: Patients with PAD and wounds of the foot and ankle who underwent STSG between January 2014 and December 2016 were retrospectively reviewed. All patients received angiographic evaluation and endovascular or open revascularization where necessary. Effects of extremity revascularizations, STSG percent take, and amputation rate were evaluated.

OBJECTIVE: In this study, the authors examine factors predictive of STSG healing in patients with PAD following vascular intervention, including the effect of non-inline flow via arterial-arterial and non-arterial collateralization.

RESULTS: Thirty-five patients with 47 wounds underwent STSG. There were 21 men and 14 women with a mean age of 64 +/- 13 years. Revascularization was required in 23 patients (25 extremities) before STSG, with balloon angioplasty for tibial artery lesions as the most common revascularization. Patent pedal arch was present in 8 patients; 35 patients had an absent or incomplete pedal arch. Patients with a fully patent pedal arch healed at a significantly higher rate than those with an absent or incomplete pedal arch at 1 month (62.5% vs. 17.1%, P < .05). At 90-day follow-up, 9 of 35 (25.7%) patients with 9 of 47 (19.1%) wounds were lost to follow-up, leaving 18 of 38 (47.37%) wounds healed and 20 (52.63%) still open. Ultimately, 36 of 47 (76.60%) wounds healed and 6 major amputations in 6 patients were required at a mean 502 +/- 342 days follow-up.

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