Prostate Cancer in Men with Treated Advanced Heart Failure: Should we keep Screening?.
Citation: Urology. 2019 Nov 28Urology. 136:46-50, 2020 Feb.PMID: 31786304Institution: MedStar Georgetown University Hospital Residents | MedStar Heart & Vascular Institute | MedStar Washington Hospital CenterDepartment: UrologyForm of publication: Journal ArticleMedline article type(s): Journal ArticleSubject headings: *Early Detection of Cancer | *Heart Failure/co [Complications] | *Heart Failure/su [Surgery] | *Heart Transplantation | *Heart-Assist Devices | *Prostatic Neoplasms/co [Complications] | *Prostatic Neoplasms/di [Diagnosis] | Adolescent | Adult | Aged | Aged, 80 and over | Cohort Studies | Humans | Male | Middle Aged | Young AdultYear: 2020Local holdings: Available online from MWHC library: 1995 - present, Available in print through MWHC library:1999-2007ISSN:- 0090-4295
Item type | Current library | Collection | Call number | Status | Date due | Barcode |
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Journal Article | MedStar Authors Catalog | Article | 31786304 | Available | 31786304 |
Available online from MWHC library: 1995 - present, Available in print through MWHC library:1999-2007
CONCLUSION: Our cohort represents the largest known cohort with heart failure treated by LVAD/HT and PCa. Our median age of 59 at PCa diagnosis is considerably younger than the national median of 66.1 Of the 4 individuals diagnosed with PCa, 3 had high grade disease. Given the favorable long-term survival of these patients post-LVAD/HT, age-appropriate treatment for PCa should be continued post-implantation. Copyright (c) 2019. Published by Elsevier Inc.
METHODS: Men aged 18-90 with normal pre-transplant PSA who underwent LVAD/HT at MWHC from 2007-2018 were identified. Serum PSA, PCa diagnosis, and treatment were captured and analyzed. Survival was analyzed using Kaplan-Meier curves.
OBJECTIVES: To evaluate the outcomes of men diagnosed with prostate cancer (PCa) following implanted treatments for advanced heart failure. Given the increasingly favorable 10-year life expectancy, MedStar Washington Hospital Center (MWHC) screens heart transplant (HT) candidates for PCa and other malignancies prior to intervention.
RESULTS: Data was available for 34 patients. Median age was 53 [IQR=51-58]. Median follow-up was 77mo (95% CI=40-87mo). Six men had post-implant elevated PSA (5.3; SD=8.5) and 4 were diagnosed with PCa. Median age of PCa diagnosis was 59 [IQR=58.5-62). As of 2018, 31 of the 34 patients were living, and none died from PCa. Five-year survival was 96% in those without PCa and 100% in those with PCa (figure 2).
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