COVID-19 Vaccination Status and Capsular Contracture Following Prosthetic Breast Reconstruction: A Retrospective, Multicenter Nested Case-Control Study.

MedStar author(s):
Citation: Aesthetic Surgery Journal. 2022 Nov 17PMID: 36395159Institution: MedStar Washington Hospital CenterDepartment: MedStar Georgetown University Hospital/MedStar Washington Hospital Center | Plastic Surgery Residency | Surgery/Plastic SurgeryForm of publication: Journal ArticleMedline article type(s): Journal ArticleSubject headings: IN PROCESS -- NOT YET INDEXEDYear: 2022ISSN:
  • 1090-820X
Name of journal: Aesthetic surgery journalAbstract: BACKGROUND: Capsular contracture (CC) is a common long-term complication following prosthetic-based breast reconstruction (PBBR). Seven cases of CC following mRNA vaccination for coronavirus 2019 (COVID-19) are reported in the literature.CONCLUSIONS: Direct association between CC and COVID-19 vaccination is difficult to prove. Given the known risk of severe COVID-19 infection among immunocompromised patients, those with breast cancer who undergo PBBR should be properly counseled on the benefits and risks of vaccination. Copyright © The Author(s) 2022. Published by Oxford University Press on behalf of the Aesthetic Society. All rights reserved. For permissions, please e-mail: [email protected]: A retrospective, multicenter nested case-control study was performed from January 2014-July 2022 of adult female patients who underwent PBBR with acellular dermal matrix placement. Cases of CC were selected if no adjuvant radiation was received and they presented for follow-up between December of 2020-July 2022. Controls included patients who met inclusion criteria but who did not experience CC in either breast. Patient demographics, breast cancer characteristics, reconstructive surgery details, postoperative complications, and COVID-19 exposure details were analyzed and correlated with CC development.OBJECTIVES: We sought to determine whether receiving the COVID-19 vaccine was associated with CC development following PBBR.RESULTS: Of a total of 230 patients (393 breasts) who received PBBR, 85 patients (135 breasts) met inclusion criteria; of which, 12 patients (19 breasts) developed CC and 73 patients (116 breasts) did not. At the time of median follow up of 18.1 months (n = 85, IQR: 12.2, 33.6), we observed no statistically significant differences between the short- or long-term complications in cases or controls. There were no significant differences in COVID-19 vaccination status, number of vaccine doses, or vaccination type between cases and controls. Vaccination status was not associated with greater odds of CC development (Odds Ratio: 1.44, 95% Confidence Interval: 0.42 to 5.37, p > 0.05).All authors: Bell AC, Berger LE, Bovill JD, Fan KL, Huffman SS, Singh A, Spoer DL, Tom LK, Truong BNFiscal year: FY2023Digital Object Identifier: Date added to catalog: 2022-12-13
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Journal Article MedStar Authors Catalog Article 36395159 Available 36395159

BACKGROUND: Capsular contracture (CC) is a common long-term complication following prosthetic-based breast reconstruction (PBBR). Seven cases of CC following mRNA vaccination for coronavirus 2019 (COVID-19) are reported in the literature.

CONCLUSIONS: Direct association between CC and COVID-19 vaccination is difficult to prove. Given the known risk of severe COVID-19 infection among immunocompromised patients, those with breast cancer who undergo PBBR should be properly counseled on the benefits and risks of vaccination. Copyright © The Author(s) 2022. Published by Oxford University Press on behalf of the Aesthetic Society. All rights reserved. For permissions, please e-mail: [email protected].

METHODS: A retrospective, multicenter nested case-control study was performed from January 2014-July 2022 of adult female patients who underwent PBBR with acellular dermal matrix placement. Cases of CC were selected if no adjuvant radiation was received and they presented for follow-up between December of 2020-July 2022. Controls included patients who met inclusion criteria but who did not experience CC in either breast. Patient demographics, breast cancer characteristics, reconstructive surgery details, postoperative complications, and COVID-19 exposure details were analyzed and correlated with CC development.

OBJECTIVES: We sought to determine whether receiving the COVID-19 vaccine was associated with CC development following PBBR.

RESULTS: Of a total of 230 patients (393 breasts) who received PBBR, 85 patients (135 breasts) met inclusion criteria; of which, 12 patients (19 breasts) developed CC and 73 patients (116 breasts) did not. At the time of median follow up of 18.1 months (n = 85, IQR: 12.2, 33.6), we observed no statistically significant differences between the short- or long-term complications in cases or controls. There were no significant differences in COVID-19 vaccination status, number of vaccine doses, or vaccination type between cases and controls. Vaccination status was not associated with greater odds of CC development (Odds Ratio: 1.44, 95% Confidence Interval: 0.42 to 5.37, p > 0.05).

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