Citation: Stroke. 43(11):2877-83, 2012 Nov..Journal: Stroke; a journal of cerebral circulation.ISSN: 0039-2499.Full author list: Falcone GJ; Biffi A; Devan WJ; Jagiella JM; Schmidt H; Kissela B; Hansen BM; Jimenez-Conde J; Giralt-Steinhauer E; Elosua R; Cuadrado-Godia E; Soriano C; Ayres AM; Schwab K; Pera J; Urbanik A; Rost NS; Goldstein JN; Viswanathan A; Pichler A; Enzinger C; Norrving B; Tirschwell DL; Selim M; Brown DL; Silliman SL; Worrall BB; Meschia JF; Kidwell CS; Montaner J; Fernandez-Cadenas I; Delgado P; Broderick JP; Greenberg SM; Roquer J; Lindgren A; Slowik A; Schmidt R; Flaherty ML; Kleindorfer DO; Langefeld CD; Woo D; Rosand J; International Stroke Genetics Consortium.UI/PMID: 22933587.Subject(s): Aged | Alleles | Case-Control Studies | Female | *Genetic Predisposition to Disease/ge [Genetics] | Genotype | Humans | Hypertension/co [Complications] | *Hypertension/ge [Genetics] | *Intracranial Hemorrhage, Hypertensive/ge [Genetics] | Male | Polymorphism, Single Nucleotide | Risk FactorsInstitution(s): MedStar Heart & Vascular InstituteActivity type: Journal Article.Medline article type(s): Journal Article | Multicenter Study | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov'tOnline resources: Click here to access onlineDigital Object Identifier: http://dx.doi.org/10.1161/STROKEAHA.112.659755 (Click here)Abbreviated citation: Stroke. 43(11):2877-83, 2012 Nov.Local Holdings: Available online from MWHC library: 1970 - present, Available in print through MWHC library: 1999 - 2006.Abstract: BACKGROUND AND PURPOSE: Genetic variation influences risk of intracerebral hemorrhage (ICH). Hypertension (HTN) is a potent risk factor for ICH and several common genetic variants (single nucleotide polymorphisms [SNPs]) associated with blood pressure levels have been identified. We sought to determine whether the cumulative burden of blood pressure-related SNPs is associated with risk of ICH and pre-ICH diagnosis of HTN.Abstract: METHODS: We conducted a prospective multicenter case-control study in 2272 subjects of European ancestry (1025 cases and 1247 control subjects). Thirty-nine SNPs reported to be associated with blood pressure levels were identified from the National Human Genome Research Institute genomewide association study catalog. Single-SNP association analyses were performed for the outcomes ICH and pre-ICH HTN. Subsequently, weighted and unweighted genetic risk scores were constructed using these SNPs and entered as the independent variable in logistic regression models with ICH and pre-ICH HTN as the dependent variables.Abstract: RESULTS: No single SNP was associated with either ICH or pre-ICH HTN. The blood pressure-based unweighted genetic risk score was associated with risk of ICH (OR, 1.11; 95% CI, 1.02-1.21; P=0.01) and the subset of ICH in deep regions (OR, 1.18; 95% CI, 1.07-1.30; P=0.001), but not with the subset of lobar ICH. The score was associated with a history of HTN among control subjects (OR, 1.17; 95% CI, 1.04-1.31; P=0.009) and ICH cases (OR, 1.15; 95% CI, 1.01-1.31; P=0.04). Similar results were obtained when using a weighted score.Abstract: CONCLUSIONS: Increasing numbers of high blood pressure-related alleles are associated with increased risk of deep ICH as well as with clinically identified HTN.