Effects of age and left hemisphere lesions on audiovisual integration of speech.

MedStar author(s):
Citation: Brain & Language. 206:104812, 2020 07.PMID: 32447050Institution: MedStar National Rehabilitation Network | MedStar Washington Hospital CenterDepartment: NeurologyForm of publication: Journal ArticleMedline article type(s): Journal ArticleSubject headings: *Aging/ph [Physiology] | *Functional Laterality/ph [Physiology] | *Speech Perception/ph [Physiology] | *Visual Perception/ph [Physiology] | Acoustic Stimulation/mt [Methods] | Aged | Aging/px [Psychology] | Auditory Perception/ph [Physiology] | Female | Humans | Male | Middle Aged | Photic Stimulation/mt [Methods]Year: 2020ISSN:
  • 0093-934X
Name of journal: Brain and languageAbstract: Neuroimaging studies have implicated left temporal lobe regions in audiovisual integration of speech and inferior parietal regions in temporal binding of incoming signals. However, it remains unclear which regions are necessary for audiovisual integration, especially when the auditory and visual signals are offset in time. Aging also influences integration, but the nature of this influence is unresolved. We used a McGurk task to test audiovisual integration and sensitivity to the timing of audiovisual signals in two older adult groups: left hemisphere stroke survivors and controls. We observed a positive relationship between age and audiovisual speech integration in both groups, and an interaction indicating that lesions reduce sensitivity to timing offsets between signals. Lesion-symptom mapping demonstrated that damage to the left supramarginal gyrus and planum temporale reduces temporal acuity in audiovisual speech perception. This suggests that a process mediated by these structures identifies asynchronous audiovisual signals that should not be integrated. Copyright (c) 2020 Elsevier Inc. All rights reserved.All authors: Anbari Z, Erickson LC, Fama ME, Lacey EH, Michaelis K, Norato G, Rauschecker JP, Skipper-Kallal LM, Turkeltaub PE, Xing SOriginally published: Brain & Language. 206:104812, 2020 May 21.Fiscal year: FY2021Digital Object Identifier: Date added to catalog: 2020-07-09
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Journal Article MedStar Authors Catalog Article 32447050 Available 32447050

Neuroimaging studies have implicated left temporal lobe regions in audiovisual integration of speech and inferior parietal regions in temporal binding of incoming signals. However, it remains unclear which regions are necessary for audiovisual integration, especially when the auditory and visual signals are offset in time. Aging also influences integration, but the nature of this influence is unresolved. We used a McGurk task to test audiovisual integration and sensitivity to the timing of audiovisual signals in two older adult groups: left hemisphere stroke survivors and controls. We observed a positive relationship between age and audiovisual speech integration in both groups, and an interaction indicating that lesions reduce sensitivity to timing offsets between signals. Lesion-symptom mapping demonstrated that damage to the left supramarginal gyrus and planum temporale reduces temporal acuity in audiovisual speech perception. This suggests that a process mediated by these structures identifies asynchronous audiovisual signals that should not be integrated. Copyright (c) 2020 Elsevier Inc. All rights reserved.

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