MedStar Authors catalog › Details for: A review of genetics, arterial stiffness, and blood pressure in African Americans. [Review]
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A review of genetics, arterial stiffness, and blood pressure in African Americans. [Review]

by Barac, Ana.
Citation: Journal of Cardiovascular Translational Research . 5(3):302-8, 2012 Jun..Journal: Journal of cardiovascular translational research.Full author list: Hall JL; Duprez DA; Barac A; Rich SS.UI/PMID: 22492025.Subject(s): *African Americans/ge [Genetics] | *Arteries/pa [Pathology] | Arteries/pp [Physiopathology] | *Blood Pressure/ge [Genetics] | Compliance | Genetic Predisposition to Disease | Heredity | Humans | Hypertension/eh [Ethnology] | *Hypertension/ge [Genetics] | Hypertension/pa [Pathology] | Hypertension/pp [Physiopathology] | Phenotype | Prevalence | Risk Assessment | Risk Factors | United States/ep [Epidemiology]Institution(s): MedStar Heart & Vascular InstituteActivity type: Journal Article.Medline article type(s): Journal Article | ReviewOnline resources: Click here to access online Digital Object Identifier: (Click here) Abbreviated citation: J Cardiovasc Transl Res. 5(3):302-8, 2012 Jun.Abstract: The prevalence of hypertension in African Americans in the USA is among the highest in the world and increasing. The identification of genes and pathways regulating blood pressure in African Americans has been challenging. An early predictor of hypertension is arterial stiffness. The prevalence of arterial stiffness is significantly higher in African Americans compared to Caucasians. Approximately 20 % of the variance in arterial stiffness is estimated to be heritable. Identifying genes and biological pathways regulating arterial stiffness may provide insight into the genetics underlying the increased risk of hypertension in African Americans. This paper reviews the genetic findings to date in the area of arterial stiffness and blood pressure in African Americans with an emphasis on the current limitations and new efforts to move the field forward.

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