MedStar Authors catalog › Details for: Chronic stress impairs collateral blood flow recovery in aged mice.
Chronic stress impairs collateral blood flow recovery in aged mice. Journal: Journal of cardiovascular translational research.UI/PMID: 25315467.Subject(s): Animals | Behavior, Animal | Chronic Disease | Cold Temperature | *Collateral Circulation | Disease Models, Animal | *Femoral Artery/pp [Physiopathology] | Femoral Artery/su [Surgery] | Ischemia/et [Etiology] | *Ischemia/pp [Physiopathology] | Ischemia/px [Psychology] | Ligation | Male | Mice, Inbred C57BL | Recovery of Function | Regional Blood Flow | Social Behavior | Stress, Psychological/et [Etiology] | *Stress, Psychological/pp [Physiopathology] | Stress, Psychological/px [Psychology] | Time FactorsInstitution(s): MedStar Health Research Institute | MedStar Heart & Vascular Institute | MedStar Washington Hospital CenterDepartment(s): Medicine/Internal MedicineActivity type: Journal Article.Medline article type(s): Journal Article | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov'tDigital Object Identifier: http://dx.doi.org/10.1007/s12265-014-9592-2 (Click here) Abbreviated citation: J Cardiovasc Transl Res. 7(8):749-55, 2014 Nov.Abstract: Chronic stress is associated with increased risk of cardiovascular diseases. Aging is also associated with vascular dysfunction. We hypothesize that chronic stress accelerates collateral dysfunction in old mice. Mice were subjected to either chronic social defeat (CSD) or chronic cold stress (CCS). The CSD mice were housed in a box inside an aggressor's cage and exposed to the aggressor. The CCS group was placed in iced water. After chronic stress, mice underwent femoral artery ligation (FAL) and flow recovery was measured. For the CSD group, appearance and use scores of the foot and a behavioral test were performed. CSD impaired collateral flow recovery after FAL. Further, stressed mice had greater ischemic damage, impaired foot function, and altered behavior. The CCS mice also showed impaired collateral flow recovery. Chronic stress causes hind limb collateral dysfunction in old mice, a conclusion reinforced by the fact that two types of stress produced similar changes.