Genetics of Smoking Behaviors in American Indians.

MedStar author(s):
Citation: Cancer Epidemiology, Biomarkers & Prevention. 29(11):2180-2186, 2020 11.PMID: 32855268Institution: MedStar Health Research InstituteForm of publication: Journal ArticleMedline article type(s): Journal ArticleSubject headings: *Smoking/ep [Epidemiology] | Adult | Aged | Aged, 80 and over | Female | Humans | Male | Middle Aged | Surveys and Questionnaires | Young AdultYear: 2020Local holdings: Available online from MWHC library: Nov 1991 - present (after 1 year)ISSN:
  • 1055-9965
Name of journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive OncologyAbstract: BACKGROUND: The smoking behavior of American Indians (AI) differs from that of non-Hispanic whites (NHW). Typically light smokers, cessation interventions in AIs are generally less effective. To develop more effective cessation programs for AIs, clinicians, researchers, and public health workers need a better understanding of the genetic factors involved in their smoking behavior. Our aim was to assess whether SNPs associated with smoking behavior in NHWs are also associated with smoking in AIs.CONCLUSIONS: The contribution of many genes known to underlie smoking behaviors in NHWs may differ in AIs.IMPACT: Once validated, these variants could be useful in developing more effective cessation strategies. Copyright (c)2020 American Association for Cancer Research.METHODS: We collected questionnaire data on smoking behaviors and analyzed blood and saliva samples from two Tribal populations with dramatically different cultures and smoking prevalence, one in the Northern Plains (n = 323) and the other in the Southwest (n = 176). A total of 384 SNPs were genotyped using an Illumina custom GoldenGate platform. Samples were also assessed for cotinine and 3-hydroxycotinine as markers of nicotine intake and nicotine metabolite ratio.RESULTS: Among 499 participants, we identified, in the Northern Plains sample only, a variant of the gamma-aminobutyric acid receptor subunit alpha-2 (GABRA2) (rs2119767) on chromosome 4p that was associated with many of the intake biomarkers of smoking we examined, suggesting a role for this gene in modifying smoking behavior in this population. We also identified three SNPs, in the Southwest sample only, as significant correlates of only cigarettes per day: rs4274224, rs4245147 (both dopamine receptor D2 gene), and rs1386493 (tryptophan hydroxylase 2 gene).All authors: Amos CI, Buchwald DS, Collaborative to Improve Native Cancer Outcomes (CINCO), a P50 Center for Population Health and Health Disparities program project sponsored by the National Cancer Institute, Gorlova OY, Henderson JA, Henderson PN, Howard BV, Li Y, Tyndale RFOriginally published: Cancer Epidemiology, Biomarkers & Prevention. 2020 Aug 27Fiscal year: FY2021Digital Object Identifier: Date added to catalog: 2020-10-06
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Item type Current library Collection Call number Status Date due Barcode
Journal Article MedStar Authors Catalog Article 32855268 Available 32855268

Available online from MWHC library: Nov 1991 - present (after 1 year)

BACKGROUND: The smoking behavior of American Indians (AI) differs from that of non-Hispanic whites (NHW). Typically light smokers, cessation interventions in AIs are generally less effective. To develop more effective cessation programs for AIs, clinicians, researchers, and public health workers need a better understanding of the genetic factors involved in their smoking behavior. Our aim was to assess whether SNPs associated with smoking behavior in NHWs are also associated with smoking in AIs.

CONCLUSIONS: The contribution of many genes known to underlie smoking behaviors in NHWs may differ in AIs.

IMPACT: Once validated, these variants could be useful in developing more effective cessation strategies. Copyright (c)2020 American Association for Cancer Research.

METHODS: We collected questionnaire data on smoking behaviors and analyzed blood and saliva samples from two Tribal populations with dramatically different cultures and smoking prevalence, one in the Northern Plains (n = 323) and the other in the Southwest (n = 176). A total of 384 SNPs were genotyped using an Illumina custom GoldenGate platform. Samples were also assessed for cotinine and 3-hydroxycotinine as markers of nicotine intake and nicotine metabolite ratio.

RESULTS: Among 499 participants, we identified, in the Northern Plains sample only, a variant of the gamma-aminobutyric acid receptor subunit alpha-2 (GABRA2) (rs2119767) on chromosome 4p that was associated with many of the intake biomarkers of smoking we examined, suggesting a role for this gene in modifying smoking behavior in this population. We also identified three SNPs, in the Southwest sample only, as significant correlates of only cigarettes per day: rs4274224, rs4245147 (both dopamine receptor D2 gene), and rs1386493 (tryptophan hydroxylase 2 gene).

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