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Comprehensive guidance on the diagnosis and management of primary mesenchymal tumours of the thyroid gland. [Review]

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Citation: Lancet Oncology. 21(11):e528-e537, 2020 11.PMID: 33152312Institution: MedStar Washington Hospital CenterDepartment: Medicine/EndocrinologyForm of publication: Journal ArticleMedline article type(s): Journal Article | ReviewSubject headings: *Biomarkers, Tumor | *Neoplasms, Connective and Soft Tissue | *Thyroid Neoplasms | Biomarkers, Tumor/an [Analysis] | Biomarkers, Tumor/ge [Genetics] | Clinical Decision-Making | Humans | Neoplasms, Connective and Soft Tissue/ch [Chemistry] | Neoplasms, Connective and Soft Tissue/ge [Genetics] | Neoplasms, Connective and Soft Tissue/pa [Pathology] | Neoplasms, Connective and Soft Tissue/th [Therapy] | Predictive Value of Tests | Prognosis | Thyroid Neoplasms/ch [Chemistry] | Thyroid Neoplasms/ge [Genetics] | Thyroid Neoplasms/pa [Pathology] | Thyroid Neoplasms/th [Therapy]Year: 2020 Local holdings: Available online from MWHC library: 2001 - presentISSN:

1470-2045

Name of journal: The Lancet. OncologyAbstract: Most primary thyroid tumours are of epithelial origin. Primary thyroid mesenchymal tumours are rare but are being increasingly detected. A vast majority of thyroid mesenchymal tumours occur between the fourth and seventh decades of life, presenting as progressively enlarging thyroid nodules that often yield non-diagnostic results or spindle cells on fine needle aspiration biopsy. Surgery is the preferred mode of treatment, with adjuvant chemoradiotherapy used for malignant thyroid mesenchymal tumours. Benign thyroid mesenchymal tumours have excellent prognosis, whereas the outcome of malignant thyroid mesenchymal tumours is variable. Each thyroid mesenchymal tumour is characterised by its unique histopathology and immunohistochemistry. Because of the rarity and aggressive nature of malignant thyroid mesenchymal tumours, a multidisciplinary team-based approach should ideally be used in the management of these tumours. Comprehensive guidelines on the management of thyroid mesenchymal tumours are currently lacking. In this Review, we provide a detailed description of thyroid mesenchymal tumours, their clinical characteristics and tumour behaviour, and provide recommendations for the optimal management of these tumours. Copyright (c) 2020 Elsevier Ltd. All rights reserved.All authors: Araque KA, Avadhanula S, Burman KD, Del Rivero J, Filie AC, Gubbi S, Kebebew E, Klubo-Gwiezdzinska J, Raffeld M, Thakur S, Wartofsky L, Welch JOriginally published: Lancet Oncology. 21(11):e528-e537, 2020 Nov.Fiscal year: FY2021Digital Object Identifier:

https://dx.doi.org/10.1016/S1470-2045(20)30332-6

Date added to catalog: 2020-12-29

Holdings ( 1 )
Title notes ( 3 )

Holdings
Item type	Current library	Collection	Call number	Status	Date due	Barcode
Journal Article	MedStar Authors Catalog	Article	33152312	Available		33152312

Available online from MWHC library: 2001 - present

Most primary thyroid tumours are of epithelial origin. Primary thyroid mesenchymal tumours are rare but are being increasingly detected. A vast majority of thyroid mesenchymal tumours occur between the fourth and seventh decades of life, presenting as progressively enlarging thyroid nodules that often yield non-diagnostic results or spindle cells on fine needle aspiration biopsy. Surgery is the preferred mode of treatment, with adjuvant chemoradiotherapy used for malignant thyroid mesenchymal tumours. Benign thyroid mesenchymal tumours have excellent prognosis, whereas the outcome of malignant thyroid mesenchymal tumours is variable. Each thyroid mesenchymal tumour is characterised by its unique histopathology and immunohistochemistry. Because of the rarity and aggressive nature of malignant thyroid mesenchymal tumours, a multidisciplinary team-based approach should ideally be used in the management of these tumours. Comprehensive guidelines on the management of thyroid mesenchymal tumours are currently lacking. In this Review, we provide a detailed description of thyroid mesenchymal tumours, their clinical characteristics and tumour behaviour, and provide recommendations for the optimal management of these tumours. Copyright (c) 2020 Elsevier Ltd. All rights reserved.

English