Citation: Annals of Thoracic Surgery. 2018 May 16.Journal: The Annals of thoracic surgery.Published: ; 2018ISSN: 0003-4975.Full author list: Rankin JS; Grau-Sepulveda M; Shahian DM; Gillinov AM; Suri R; Gammie JS; Bolling SF; McCarthy PM; Thourani VH; Ad N; O'Brien SM; Jacobs JP; Badhwar V.UI/PMID: 29777670.Subject(s): IN PROCESS -- NOT YET INDEXEDInstitution(s): MedStar Heart & Vascular InstituteActivity type: Journal Article.Medline article type(s): Journal ArticleOnline resources: Click here to access onlineDigital Object Identifier: https://dx.doi.org/10.1016/j.athoracsur.2018.04.053 (Click here)Abbreviated citation: Ann Thorac Surg. 2018 May 16.Local Holdings: Available online from MWHC library: 1995 - present, Available in print through MWHC library:1999-2007.Abstract: BACKGROUND: The pathoetiology of mitral regurgitation (MR) has been suggested as a mediator of outcomes after mitral valve (MV) operations, particularly in ischemic functional mitral regurgitation (IMR). This study examined the independent association of MV etiology with mortality.Abstract: METHODS: The Society of Thoracic Surgeons Database was utilized to assess all patients undergoing MV replacement or repair from 2011 to 2014. Patients who underwent concomitant surgical ablation, septal defect closure, tricuspid valve repair, or coronary artery bypass grafting were included. All other concomitant operations were excluded, producing a final cohort of 89,085 patients. A hierarchical etiology decision tree was developed to categorize the population into eight etiology groups: endocarditis, reoperation, acute IMR, rheumatic, uncommon etiologies (hypertrophic obstructive cardiomyopathy, trauma, tumor, or congenital), degenerative primary MR, chronic IMR, and pure annular dilatation. The statistical association of etiology with unadjusted and risk-adjusted operative mortality was evaluated by logistic regression and supplemented by sensitivity analyses using established risk models.Abstract: RESULTS: The decision tree showed that etiology categories appeared clinically aligned with published population distributions, baseline characteristics, and unadjusted outcomes. Unadjusted operative mortality ranged from 1.2% for degenerative MV repair to 15.1% for MV replacement in acute IMR. After risk adjustment, MV etiologies per se exhibited insignificant independent associations with risk-adjusted operative mortality.Abstract: CONCLUSIONS: Mortality after mitral operations is determined primarily by standard clinical risk factors. Mitral etiology does not appear to add independent predictive value.Abstract: Copyright (c) 2018 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.