Citation: Journal of Perinatology. 2018 Sep 12.Journal: Journal of perinatology : official journal of the California Perinatal Association.Published: ; 2018ISSN: 0743-8346.Full author list: Drumm CM; Siddiqui JN; Desale S; Ramasethu J.UI/PMID: 30209351.Subject(s): IN PROCESS -- NOT YET INDEXEDInstitution(s): MedStar Health Research Institute | MedStar Washington Hospital CenterDepartment(s): Neonatology and PediatricsActivity type: Journal Article.Medline article type(s): Journal ArticleDigital Object Identifier: https://dx.doi.org/10.1038/s41372-018-0226-4 (Click here)Abbreviated citation: J Perinatol. 2018 Sep 12.Local Holdings: Available online through MWHC library: 1999 - 2009, Available in print through MWHC library: 1999 - 2006.Abstract: OBJECTIVE: Determine the significance of urinary tract infection (UTI) as a cause of late onset sepsis (LOS) in very low birth weight (VLBW) infants in the Neonatal Intensive Care Unit (NICU).Abstract: STUDY DESIGN: Analysis of blood, cerebrospinal fluid and urine culture results in VLBW infants >72-h old, admitted to the Georgetown University Hospital NICU between 2005 and 2015.Abstract: RESULT: Of 527 VLBW infants, 297 (56.4%) underwent 911 evaluations for LOS; only one-third included urine cultures. UTI was diagnosed in 8.5% of VLBW infants (range 2-15.9%) and in 13.8% of infants weighing < 1000 g at birth. Gram-negative infections predominated. Concomitant blood cultures were negative in 96% of infants. UTI was more common than bloodstream infection by 2015.Abstract: CONCLUSION: UTI is a significant cause of infection in VLBW infants. Urine culture should be included in all LOS evaluations in order to facilitate accurate diagnosis and appropriate antibiotic therapy.