MedStar Authors catalog › Details for: Coronary fractional flow reserve derived from intravascular ultrasound imaging: Validation of a new computational method of fusion between anatomy and physiology.
Citation: Catheterization & Cardiovascular Interventions. 2018 Sep 12.Journal: Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions.Published: ; 2018ISSN: 1522-1946.Full author list: Bezerra CG; Hideo-Kajita A; Bulant CA; Maso-Talou GD; Mariani J Jr; Pinton FA; Falcao BAA; Esteves-Filho A; Franken M; Feijoo RA; Kalil-Filho R; Garcia-Garcia HM; Blanco PJ; Lemos PA.UI/PMID: 30277641.Subject(s): IN PROCESS -- NOT YET INDEXEDInstitution(s): MedStar Heart & Vascular InstituteActivity type: Journal Article.Medline article type(s): Journal ArticleOnline resources: Click here to access onlineDigital Object Identifier: https://dx.doi.org/10.1002/ccd.27822 (Click here)ORCID: Bezerra, Cristiano G http://orcid.org/0000-0002-4762-0579Lemos, Pedro A http://orcid.org/0000-0002-6782-750X (Click here) | (Click here)Abbreviated citation: Catheter Cardiovasc Interv. 2018 Sep 12.Local Holdings: Available online from MWHC library: 1996 - present, Available in print through MWHC library: 1996 - 2006.Abstract: OBJECTIVES: To evaluate the diagnostic performance of a novel computational algorithm based on three-dimensional intravascular ultrasound (IVUS) imaging in estimating fractional flow reserve (IVUS<sub>FR</sub>), compared to gold-standard invasive measurements (FFR<sub>INVAS</sub>).Abstract: BACKGROUND: IVUS provides accurate anatomical evaluation of the lumen and vessel wall and has been validated as a useful tool to guide percutaneous coronary intervention. However, IVUS poorly represents the functional status (i.e., flow-related information) of the imaged vessel.Abstract: METHODS: Patients with known or suspected stable coronary disease scheduled for elective cardiac catheterization underwent FFR<sub>INVAS</sub> measurement and IVUS imaging in the same procedure to evaluate intermediate lesions. A processing methodology was applied on IVUS to generate a computational mesh condensing the geometric characteristics of the vessel. Computation of IVUS<sub>FR</sub> was obtained from patient-level morphological definition of arterial districts and from territory-specific boundary conditions. FFR<sub>INVAS</sub> measurements were dichotomized at the 0.80 threshold to define hemodynamically significant lesions.Abstract: RESULTS: A total of 24 patients with 34 vessels were analyzed. IVUS<sub>FR</sub> significantly correlated (r = 0.79; P < 0.001) and showed good agreement with FFR<sub>INVAS</sub>, with a mean difference of -0.008 +/- 0.067 (P = 0.47). IVUS<sub>FR</sub> presented an overall accuracy, sensitivity, specificity, positive predictive value, and negative predictive value of 91%, 89%, 92%, 80%, and 96%, respectively, to detect significant stenosis.Abstract: CONCLUSION: The computational processing of IVUS<sub>FR</sub> is a new method that allows the evaluation of the functional significance of coronary stenosis in an accurate way, enriching the anatomical information of grayscale IVUS.Abstract: Copyright (c) 2018 Wiley Periodicals, Inc.