Association of Serum Triglyceride Levels with Severity in Acute Pancreatitis: Results from an International, Multicenter Cohort Study.

MedStar author(s):
Citation: Digestion. 102(5):809-813, 2021.PMID: 33477149Institution: MedStar Washington Hospital CenterDepartment: Medicine/General Internal MedicineForm of publication: Journal ArticleMedline article type(s): NewsSubject headings: *Pancreatitis | Acute Disease | Cohort Studies | Female | Humans | Male | Retrospective Studies | Risk Factors | Severity of Illness Index | TriglyceridesYear: 2021ISSN:
  • 0012-2823
Name of journal: DigestionAbstract: BACKGROUND: Hypertriglyceridemia (HTG) is considered within the top 5 etiologies in acute pancreatitis (AP), but the association of serum triglyceride (TG) levels with the clinical course of AP remains controversial.CONCLUSION: This large multicenter study confirms that elevated TG levels are associated with severe disease regardless of AP etiology. Copyright (c) 2021 S. Karger AG, Basel.METHODS: Patients were enrolled prospectively through APPRENTICE. High TG levels were defined based on the Endocrine Society Clinical Practice Guidelines. HTG was categorized as mild (serum TG levels 150-199 mg/dL), moderate (200-999 mg/dL), severe (1,000-1,999 mg/dL), and very severe (>=2,000 mg/dL). Severity of AP was based on the revised Atlanta classification criteria.OBJECTIVES: This study aims to examine the effect of TG levels on severity of AP.RESULTS: Early TG levels were measured in 764 subjects and found elevated in 342 (120 with mild; 176, moderate; and 46, severe/very severe HTG). Patients with increased TG levels were younger (age >=60, 16.7 vs. 30.3%), more likely to be male (66.1 vs. 51.2%), with more frequent alcohol use (62.8 vs. 50.7%), and diabetes mellitus (30.2 vs. 12.3%; all p <= 0.005). Severe AP (24.9 vs. 10.0%), ICU admission (32.5 vs. 19.7%), and mortality (5.3 vs. 1.7%; all p <= 0.005) were more frequently seen in patients with elevated TG levels. Based on multivariable analysis, elevated TG levels were independently associated with severe AP (p < 0.05).All authors: Archibugi L, Capurso G, Lahooti A, Papachristou GI, Paragomi P, Pothoulakis I, Tuft MOriginally published: Digestion. :1-5, 2021 Jan 21Fiscal year: FY2021Digital Object Identifier: Date added to catalog: 2021-02-17
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Journal Article MedStar Authors Catalog Article 33477149 Available 33477149

BACKGROUND: Hypertriglyceridemia (HTG) is considered within the top 5 etiologies in acute pancreatitis (AP), but the association of serum triglyceride (TG) levels with the clinical course of AP remains controversial.

CONCLUSION: This large multicenter study confirms that elevated TG levels are associated with severe disease regardless of AP etiology. Copyright (c) 2021 S. Karger AG, Basel.

METHODS: Patients were enrolled prospectively through APPRENTICE. High TG levels were defined based on the Endocrine Society Clinical Practice Guidelines. HTG was categorized as mild (serum TG levels 150-199 mg/dL), moderate (200-999 mg/dL), severe (1,000-1,999 mg/dL), and very severe (>=2,000 mg/dL). Severity of AP was based on the revised Atlanta classification criteria.

OBJECTIVES: This study aims to examine the effect of TG levels on severity of AP.

RESULTS: Early TG levels were measured in 764 subjects and found elevated in 342 (120 with mild; 176, moderate; and 46, severe/very severe HTG). Patients with increased TG levels were younger (age >=60, 16.7 vs. 30.3%), more likely to be male (66.1 vs. 51.2%), with more frequent alcohol use (62.8 vs. 50.7%), and diabetes mellitus (30.2 vs. 12.3%; all p <= 0.005). Severe AP (24.9 vs. 10.0%), ICU admission (32.5 vs. 19.7%), and mortality (5.3 vs. 1.7%; all p <= 0.005) were more frequently seen in patients with elevated TG levels. Based on multivariable analysis, elevated TG levels were independently associated with severe AP (p < 0.05).

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