Citation: Journal of Infectious Diseases. 2018 Oct 15.Journal: The Journal of infectious diseases.Published: ; 2018ISSN: 0022-1899.Full author list: Lee NR; Winer RL; Cherne S; Noonan CJ; Nelson L; Gonzales AA; Umans JG; Buchwald D; Collaborative to Improve Native Cancer Outcomes (CINCO).UI/PMID: 30321371.Subject(s): IN PROCESS -- NOT YET INDEXEDInstitution(s): MedStar Health Research InstituteActivity type: Journal Article.Medline article type(s): Journal ArticleOnline resources: Click here to access onlineDigital Object Identifier: https://dx.doi.org/10.1093/infdis/jiy600 (Click here)Abbreviated citation: J Infect Dis. 2018 Oct 15.Local Holdings: Available online from MWHC library: April 1997 - present, Available in print through MWHC library: 1999 - present.Abstract: Background: High-risk human papillomavirus (HrHPV) causes cervical cancer. In the U.S., approximately 40% of women aged 14-59 years from all racial and ethnic groups are infected with HPV, and prevalence typically declines with age. However, American Indian women are insufficiently sampled to permit a population-specific estimate of HrHPV prevalence.Abstract: Methods: Vaginal swabs were self-collected by 698 AI women aged 21-65 years from a tribal community in the Great Plains. We estimated the population prevalence of HrHPV and identified predominant genotypes.Abstract: Results: The combined prevalence of HrHPV genotypes 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, and 68 was 34.8%. HPV-51 (7.6%), HPV-58 (5.3%), HPV-52 (4.3%), HPV-18 (4.3%), and HPV-16 (3.9%) were most prevalent. HrHPV prevalence declined with age, from 42.2% in women aged 21-24 years to 27.9% in women aged 50-65 years.Abstract: Conclusion: HPV-51 was the single most prevalent oncogenic genotype. The combined prevalence of HrHPV among AI women in our sample was high, particularly among women aged 50-65 years, for whom HrHPV prevalence was approximately triple that of other races. Cervical cancer screening efforts should be increased particularly among women from the community aged 30 years and older.