Cutaneous Keratocyst With D2-40 Immunoreactivity in Basal Cell Nevus Syndrome.

MedStar author(s):
Citation: American Journal of Dermatopathology. 43(9):659-661, 2021 Sep 01.PMID: 33606372Institution: MedStar Washington Hospital CenterDepartment: DermatologyForm of publication: Journal ArticleMedline article type(s): Journal ArticleSubject headings: *Basal Cell Nevus Syndrome/me [Metabolism] | *Epidermal Cyst/me [Metabolism] | *Membrane Glycoproteins/me [Metabolism] | *Skin Neoplasms/me [Metabolism] | Antibodies, Monoclonal, Murine-Derived | Basal Cell Nevus Syndrome/pa [Pathology] | Child | Female | Humans | Odontogenic Cysts/me [Metabolism] | Skin Neoplasms/pa [Pathology]Year: 2021Local holdings: Available online from MWHC library: Feb 1996 - presentISSN:
  • 0193-1091
Name of journal: The American Journal of dermatopathologyAbstract: ABSTRACT: Although not a diagnostic criterion for basal cell nevus syndrome (BCNS, OMIM#109400), cutaneous cysts, particularly epidermoid cysts, are common in this condition. Cutaneous keratocysts, on the other hand, are extremely rare in general and have been identified in only 5 patients with BCNS. Here, we describe a BCNS patient with a cutaneous keratocyst that demonstrated D2-40 (podoplanin) immunoreactivity, which has been detected in odontogenic keratocysts but not cutaneous keratocysts. This finding suggests that cutaneous keratocysts may be developmentally homologous to odontogenic keratocysts and may behave similarly in terms of invasion and growth pattern. Copyright (c) 2021 Wolters Kluwer Health, Inc. All rights reserved.All authors: Anatelli F, Goggins CA, Norton SA, Zerah MLOriginally published: American Journal of Dermatopathology. 2021 Feb 16Fiscal year: FY2022Fiscal year of original publication: FY2021Digital Object Identifier: Date added to catalog: 2021-03-10
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Item type Current library Collection Call number Status Date due Barcode
Journal Article MedStar Authors Catalog Article 33606372 Available 33606372

Available online from MWHC library: Feb 1996 - present

ABSTRACT: Although not a diagnostic criterion for basal cell nevus syndrome (BCNS, OMIM#109400), cutaneous cysts, particularly epidermoid cysts, are common in this condition. Cutaneous keratocysts, on the other hand, are extremely rare in general and have been identified in only 5 patients with BCNS. Here, we describe a BCNS patient with a cutaneous keratocyst that demonstrated D2-40 (podoplanin) immunoreactivity, which has been detected in odontogenic keratocysts but not cutaneous keratocysts. This finding suggests that cutaneous keratocysts may be developmentally homologous to odontogenic keratocysts and may behave similarly in terms of invasion and growth pattern. Copyright (c) 2021 Wolters Kluwer Health, Inc. All rights reserved.

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