Citation: Head & Neck. 2018 Dec 11.Journal: Head & neck.Published: ; 2018ISSN: 1043-3074.Full author list: Lumley CJ; Kaffenberger TM; Desale S; Tefera E; Han CJ; Rafei H; Maxwell JH.UI/PMID: 30537085.Subject(s): IN PROCESS -- NOT YET INDEXEDInstitution(s): MedStar Health Research Institute | MedStar Washington Hospital CenterDepartment(s): OtolaryngologyActivity type: Journal Article.Medline article type(s): Journal ArticleDigital Object Identifier: https://dx.doi.org/10.1002/hed.25518 (Click here)ORCID: Lumley, Catherine J https://orcid.org/0000-0001-8609-9002 (Click here)Abbreviated citation: Head Neck. 2018 Dec 11.Local Holdings: Available online from MWHC library: 1996 - present.Abstract: BACKGROUND: Our objective was to determine the effect of post-diagnosis aspirin use on survival in veterans with head and neck squamous cell carcinoma.Abstract: METHODS: Retrospective cohort study of 584 veterans with head and neck squamous cell carcinoma treated at the Washington DC VA Medical Center between 1995 and 2015. Charts were queried for clinical-pathologic data, aspirin prescriptions, and outcome. The Kaplan-Meier method was used to determine overall survival (OS) and disease-specific survival (DSS) among aspirin users and nonusers.Abstract: RESULTS: A total of 329 patients met inclusion criteria. Primary subsites included oropharynx (n = 143), larynx (n = 105), oral cavity (n = 62), and hypopharynx (n = 19). Eighty-four patients were aspirin users (25.5%). Aspirin users demonstrated significantly better 3-year OS and DSS (78.6% and 88.1%) compared to nonaspirin users (OS: 55.9% and DSS: 70.2%; P = .0003 and P = .0019, respectively). On multivariate analysis, aspirin use remained independently associated with improved survival.Abstract: CONCLUSION: Aspirin use following diagnosis and curative treatment of head and neck squamous cell carcinoma is associated with improved OS and DSS.Abstract: Copyright (c) 2018 Wiley Periodicals, Inc.