MedStar Authors catalog › Details for: Serial 3-Dimensional Optical Coherence Tomography Assessment of Jailed Side-Branch by Second-Generation Drug-Eluting Absorbable Metal Scaffold (from the BIOSOLVE-II Trial).
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Serial 3-Dimensional Optical Coherence Tomography Assessment of Jailed Side-Branch by Second-Generation Drug-Eluting Absorbable Metal Scaffold (from the BIOSOLVE-II Trial).

by Garcia-Garcia, Hector M; Hideo-Kajita, Alexandre; Kuku, Kayode; Ozaki, Yuichi; Waksman, Ron.
Citation: American Journal of Cardiology. 123(7):1044-1051, 2019 04 01.; .Journal: The American journal of cardiology.Published: 2019; ISSN: 0002-9149.Full author list: Abizaid A; Christiansen EH; Escaned J; Garcia-Garcia HM; Haude M; Hideo-Kajita A; Ince H; Kuku KO; Lemos PA; Ozaki Y; Tolg R; von Birgelen C; Waksman R; Wijns W.UI/PMID: 30683424.Subject(s): *Absorbable Implants | *Coronary Artery Disease/su [Surgery] | *Coronary Vessels/dg [Diagnostic Imaging] | *Drug-Eluting Stents | *Imaging, Three-Dimensional/mt [Methods] | *Percutaneous Coronary Intervention/mt [Methods] | *Tomography, Optical Coherence/mt [Methods] | Aged | Coronary Artery Disease/di [Diagnosis] | Coronary Vessels/su [Surgery] | Female | Follow-Up Studies | Humans | Male | Prospective Studies | Prosthesis Design | Reproducibility of Results | Tissue Scaffolds | Treatment OutcomeInstitution(s): MedStar Heart & Vascular Institute | MedStar Washington Hospital CenterActivity type: Journal Article.Medline article type(s): Journal ArticleDigital Object Identifier: https://dx.doi.org/10.1016/j.amjcard.2018.12.029 (Click here) Abbreviated citation: Am J Cardiol. 123(7):1044-1051, 2019 04 01; .Local Holdings: Available online from MWHC library: 1995 - present, Available in print through MWHC library: 1999 - 2006.Abstract: Copyright (c) 2019. Published by Elsevier Inc.Abstract: Second-generation drug-eluting absorbable metal scaffold (DREAMS 2G) is used for treating coronary lesions. However, the natural history of the jailed side-branch (SB) after DREAMS 2G implantation remains to be elucidated. The aim of this study is to investigate the effect of scaffold struts on jailed SBs as assessed by 3-dimensional (3D) optical coherence tomography (OCT) after implantation of DREAMS 2G. We enrolled the patients who received a DREAMS 2G implantation and where OCT was performed at postprocedure and 12-month follow-up in the BIOSOLVE-II trial. The area of the ostium of jailed SBs and number of compartments divided by scaffold struts were assessed by cut-plane analysis using 3D OCT. A total of 24 patients with 61 jailed SBs were analyzed in this study. The number of compartments was significantly decreased (postprocedure; 1.98 +/- 0.84 vs 12 months; 1.10 +/- 0.30, p <0.001) during the 12 months. Since most of the struts disappeared, the ostium area was increased in 62% of jailed SBs at 12 months, however, not significantly different from postprocedure (postprocedure; 0.74 [0.34 to 1.46] mm<sup>2</sup> vs 12 months; 0.78 [0.41 to 1.68] mm<sup>2</sup>, p=0.055). The number of compartments created by scaffold struts and branching angle at postprocedure had no effect on the changes of SB ostium area. DREAMS 2G has a favorable absorption process in the jailed SBs up to 12 months and may be considered as an optional therapy for treating lesions that involve SBs.

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