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Impact of human immunodeficiency virus infection on Takotsubo cardiomyopathy outcomes in a large nationwide sample.

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Citation: Cardiovascular Revascularization Medicine. 2021 May 19PMID: 34049819Institution: MedStar Health Research Institute | MedStar Heart & Vascular Institute | MedStar Washington Hospital CenterDepartment: Internal Medicine ResidencyForm of publication: Journal ArticleMedline article type(s): Journal ArticleSubject headings: IN PROCESS -- NOT YET INDEXEDYear: 2021 Local holdings: Available in print through MWHC library: 2002 - presentISSN:

1878-0938

Name of journal: Cardiovascular revascularization medicine : including molecular interventionsAbstract: BACKGROUND/PURPOSE: Takotsubo Cardiomyopathy (TCM) or stress-induced cardiomyopathy is characterized by transient wall motion abnormalities often preceded by physical or emotional stress. Various baseline medical comorbidities were associated with worse outcomes theoretically due to their effect on chronic stress exposure. The effect of concurrent Human Immunodeficiency Virus (HIV) infection on outcomes of TCM has not been well established.CONCLUSION: TCM patient with concurrent HIV had numerically worse outcomes. After adjusting for potential confounders, the statistical significance no longer existed. Suggesting that statistical difference was primarily driven by difference in baseline sociodemographic parameters and coexisting comorbidities. Copyright (c) 2021. Published by Elsevier Inc.METHODS/MATERIAL: We conducted a US-wide analysis of TCM hospitalizations from 2006 to 2014 by querying the National Inpatient Sample database for the International Classification of Diseases-ninth Revision TCM code, baseline characteristics, and inpatient outcomes. TCM patients with HIV were compared to TCM patients without HIV. Multivariate regression models were constructed to account for potential confounders.RESULTS: We identified 123,050 patients hospitalized with TCM, of those patients 304 had positive HIV status. In an unadjusted analysis, in-hospital outcomes were worse in TCM patients with HIV infection in terms of development of acute kidney injury (16.8% vs 33.3%, P-value 0.002), use of invasive mechanical ventilation (18.3% vs 34.5%, P-value 0.003), and mortality (5.3% vs 17.1%, P-value <0.0001). After adjusting for age, gender, and comorbidities there was no significant difference in the captured outcomes.All authors: Ali L, Desale S, Garcia-Garcia HM, Ghazzal A, Radwan SFiscal year: FY2021 Digital Object Identifier:

https://dx.doi.org/10.1016/j.carrev.2021.05.014

Date added to catalog: 2021-06-28

Holdings ( 1 )
Title notes ( 6 )

Holdings
Item type	Current library	Collection	Call number	Status	Date due	Barcode
Journal Article	MedStar Authors Catalog	Article	34049819	Available		34049819

Available in print through MWHC library: 2002 - present

BACKGROUND/PURPOSE: Takotsubo Cardiomyopathy (TCM) or stress-induced cardiomyopathy is characterized by transient wall motion abnormalities often preceded by physical or emotional stress. Various baseline medical comorbidities were associated with worse outcomes theoretically due to their effect on chronic stress exposure. The effect of concurrent Human Immunodeficiency Virus (HIV) infection on outcomes of TCM has not been well established.

CONCLUSION: TCM patient with concurrent HIV had numerically worse outcomes. After adjusting for potential confounders, the statistical significance no longer existed. Suggesting that statistical difference was primarily driven by difference in baseline sociodemographic parameters and coexisting comorbidities. Copyright (c) 2021. Published by Elsevier Inc.

METHODS/MATERIAL: We conducted a US-wide analysis of TCM hospitalizations from 2006 to 2014 by querying the National Inpatient Sample database for the International Classification of Diseases-ninth Revision TCM code, baseline characteristics, and inpatient outcomes. TCM patients with HIV were compared to TCM patients without HIV. Multivariate regression models were constructed to account for potential confounders.

RESULTS: We identified 123,050 patients hospitalized with TCM, of those patients 304 had positive HIV status. In an unadjusted analysis, in-hospital outcomes were worse in TCM patients with HIV infection in terms of development of acute kidney injury (16.8% vs 33.3%, P-value 0.002), use of invasive mechanical ventilation (18.3% vs 34.5%, P-value 0.003), and mortality (5.3% vs 17.1%, P-value <0.0001). After adjusting for age, gender, and comorbidities there was no significant difference in the captured outcomes.

English