Normal view MARC view ISBD view

Comparison of 3D-printed Titanium-Alloy, Standard Titanium-Alloy, and PEEK Interbody Spacers in an Ovine Model.

MedStar author(s):

Citation: Spine Journal: Official Journal of the North American Spine Society. 2021 May 21PMID: 34029756Institution: MedStar Union Memorial HospitalForm of publication: Journal ArticleMedline article type(s): Journal ArticleSubject headings: IN PROCESS -- NOT YET INDEXEDYear: 2021 ISSN:

1529-9430

Name of journal: The spine journal : official journal of the North American Spine SocietyAbstract: BACKGROUND CONTEXT: Osseointegration is a pivotal process in achieving a rigid fusion and ultimately a successful clinical outcome following interbody fusion surgery. Advancements in 3D printing technology permit commonly used titanium interbody spacers to be designed with unique architectures, such as a highly interconnected and specific porous structure that mimics the architecture of trabecular bone. Interbody implants with a microscale surface roughness and biomimetic porosity may improve bony ongrowth and ingrowth compared to traditional materials.CLINICAL SIGNIFICANCE: Based on these findings, the 3DP spacers may be a reasonable alternative to traditional PEEK and TAV spacers in various clinical applications of interbody fusion. Copyright (c) 2021. Published by Elsevier Inc.CONCLUSIONS: 3DP interbody spacers facilitated greater total bony ingrowth at 6 weeks, and greater bony ongrowth postoperatively at both 6 and 12 weeks, in comparison to solid PEEK and TAV implants.PURPOSE: The purpose of this study was to compare the osseointegration of lumbar interbody fusion devices composed of surgical-grade polyetheretherketone (PEEK), titanium-alloy (TAV), and 3D-printed porous, biomimetic TAV (3DP) using an in vivo ovine model.RESULTS: The 3DP-treatment group demonstrated significantly higher BV than the PEEK and TAV groups at 6 weeks (77.3+/-44.1 mm3, 116.9+/-43.0 mm3, and 108.7+/-15.2 mm3, respectively) (p<0.05). At 12 weeks, there were no BV differences between groups (p>0.05). BV increased in all groups from the 6- to 12-week time points (p<0.05). At both time points, the 3DP-treated group (6w: 23.6+/-10.9%; 12w: 36.5+/-10.9%) had significantly greater BAR than the PEEK (6w: 8.6+/-2.1%; 12w: 14.0+/-5.0%) and TAV (6w: 6.0+/-5.7%; 12w: 4.1+/-3.3%) groups (p<0.05).STUDY DESIGN: In Vivo Preclinical Animal Study METHODS: Eighteen sheep underwent two-level lateral lumbar interbody fusion randomized with either 3DP, PEEK, or TAV interbody spacers (n=6 levels for each spacer per time point). Postoperative time points were 6 and 12 weeks. Microcomputed tomography and histomorphometry were used to quantify bone volume (BV) within the spacers (ingrowth) and the surface bone apposition ratio (BAR) (ongrowth), respectively.All authors: Allall M, Beard R, Bucklen BS, Cunningham BW, Mullinix KP, Van Horn MR, Wang WFiscal year: FY2021 Digital Object Identifier:

https://dx.doi.org/10.1016/j.spinee.2021.05.018

Date added to catalog: 2021-06-28

Holdings ( 1 )
Title notes ( 7 )

Holdings
Item type	Current library	Collection	Call number	Status	Date due	Barcode
Journal Article	MedStar Authors Catalog	Article	34029756	Available		34029756

BACKGROUND CONTEXT: Osseointegration is a pivotal process in achieving a rigid fusion and ultimately a successful clinical outcome following interbody fusion surgery. Advancements in 3D printing technology permit commonly used titanium interbody spacers to be designed with unique architectures, such as a highly interconnected and specific porous structure that mimics the architecture of trabecular bone. Interbody implants with a microscale surface roughness and biomimetic porosity may improve bony ongrowth and ingrowth compared to traditional materials.

CLINICAL SIGNIFICANCE: Based on these findings, the 3DP spacers may be a reasonable alternative to traditional PEEK and TAV spacers in various clinical applications of interbody fusion. Copyright (c) 2021. Published by Elsevier Inc.

CONCLUSIONS: 3DP interbody spacers facilitated greater total bony ingrowth at 6 weeks, and greater bony ongrowth postoperatively at both 6 and 12 weeks, in comparison to solid PEEK and TAV implants.

PURPOSE: The purpose of this study was to compare the osseointegration of lumbar interbody fusion devices composed of surgical-grade polyetheretherketone (PEEK), titanium-alloy (TAV), and 3D-printed porous, biomimetic TAV (3DP) using an in vivo ovine model.

RESULTS: The 3DP-treatment group demonstrated significantly higher BV than the PEEK and TAV groups at 6 weeks (77.3+/-44.1 mm3, 116.9+/-43.0 mm3, and 108.7+/-15.2 mm3, respectively) (p<0.05). At 12 weeks, there were no BV differences between groups (p>0.05). BV increased in all groups from the 6- to 12-week time points (p<0.05). At both time points, the 3DP-treated group (6w: 23.6+/-10.9%; 12w: 36.5+/-10.9%) had significantly greater BAR than the PEEK (6w: 8.6+/-2.1%; 12w: 14.0+/-5.0%) and TAV (6w: 6.0+/-5.7%; 12w: 4.1+/-3.3%) groups (p<0.05).

STUDY DESIGN: In Vivo Preclinical Animal Study METHODS: Eighteen sheep underwent two-level lateral lumbar interbody fusion randomized with either 3DP, PEEK, or TAV interbody spacers (n=6 levels for each spacer per time point). Postoperative time points were 6 and 12 weeks. Microcomputed tomography and histomorphometry were used to quantify bone volume (BV) within the spacers (ingrowth) and the surface bone apposition ratio (BAR) (ongrowth), respectively.

English