Outcomes of renal replacement therapy in the critically ill with COVID-19.

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Citation: Med Intensiva (Engl Ed). 2021 Feb 18PMID: 33726959Institution: MedStar Washington Hospital CenterDepartment: Internal Medicine ResidencyForm of publication: Journal ArticleMedline article type(s): Journal ArticleSubject headings: IN PROCESS -- NOT YET INDEXEDYear: 2021ISSN:
  • 2173-5727
Name of journal: Medicina intensivaAbstract: CONCLUSIONS: In our cohort, acute kidney injury requiring renal replacement therapy was associated to a high mortality rate similar to that associated to the need for mechanical ventilation, while multiorgan failure necessitating both techniques implied an extremely high mortality risk. Copyright (c) 2021 Elsevier Espana, S.L.U. y SEMICYUC. All rights reserved.DESIGN: A single-center prospective observational study was carried out.INTERVENTION: Renal replacement therapy.MAIN VARIABLES OF INTEREST: Demographic data, medical history, illness severity, type of oxygen therapy, laboratory data and use of renal replacement therapy to generate a logistic regression model describing independent risk factors for mortality.OBJECTIVE: To describe outcomes of critically ill patients with COVID-19, particularly the association of renal replacement therapy to mortality.PATIENTS: Consecutive adults with COVID-19 admitted to the ICU.RESULTS: Of the total of 166 patients, 51% were mechanically ventilated and 26% required renal replacement therapy. The overall hospital mortality rate was 36%, versus 56% for those requiring renal replacement therapy, and 68% for those with both mechanical ventilation and renal replacement therapy. The logistic regression model identified four independent risk factors for mortality: age (adjusted OR 2.8 [95% CI 1.8-4.4] for every 10-year increase), mechanical ventilation (4.2 [1.7-10.6]), need for continuous venovenous hemofiltration (2.3 [1.3-4.0]) and C-reactive protein (1.1 [1.0-1.2] for every 10mg/L increase).SETTING: ICU of a tertiary care center.All authors: Burke E, Haber E, Pike CW, Sonti RFiscal year: FY2021Digital Object Identifier: Date added to catalog: 2021-06-28
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Journal Article MedStar Authors Catalog Article 33726959 Available 33726959

CONCLUSIONS: In our cohort, acute kidney injury requiring renal replacement therapy was associated to a high mortality rate similar to that associated to the need for mechanical ventilation, while multiorgan failure necessitating both techniques implied an extremely high mortality risk. Copyright (c) 2021 Elsevier Espana, S.L.U. y SEMICYUC. All rights reserved.

DESIGN: A single-center prospective observational study was carried out.

INTERVENTION: Renal replacement therapy.

MAIN VARIABLES OF INTEREST: Demographic data, medical history, illness severity, type of oxygen therapy, laboratory data and use of renal replacement therapy to generate a logistic regression model describing independent risk factors for mortality.

OBJECTIVE: To describe outcomes of critically ill patients with COVID-19, particularly the association of renal replacement therapy to mortality.

PATIENTS: Consecutive adults with COVID-19 admitted to the ICU.

RESULTS: Of the total of 166 patients, 51% were mechanically ventilated and 26% required renal replacement therapy. The overall hospital mortality rate was 36%, versus 56% for those requiring renal replacement therapy, and 68% for those with both mechanical ventilation and renal replacement therapy. The logistic regression model identified four independent risk factors for mortality: age (adjusted OR 2.8 [95% CI 1.8-4.4] for every 10-year increase), mechanical ventilation (4.2 [1.7-10.6]), need for continuous venovenous hemofiltration (2.3 [1.3-4.0]) and C-reactive protein (1.1 [1.0-1.2] for every 10mg/L increase).

SETTING: ICU of a tertiary care center.

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