Citation: American Journal of Cardiology. 123(10):1620-1625, 2019 May 15..Journal: The American journal of cardiology.Published: 2019; ISSN: 0002-9149.Full author list: Gass ML; Hall PS; Howard BV; Manson JE; Nah G; Parikh NI; Park K; Parker DR; Salmoirago-Blotcher E; Sarto GE; Sealy-Jefferson SM; Shadyab AH; Stefanick ML; Van Horn LV; Vittinghoff E.UI/PMID: 30871746.Subject(s): *Abortion, Spontaneous/ep [Epidemiology] | *Cardiovascular Diseases/et [Etiology] | *Postmenopause | *Risk Assessment/mt [Methods] | *Women's Health | Cardiovascular Diseases/ep [Epidemiology] | Female | Humans | Incidence | Middle Aged | Pregnancy | Prospective Studies | Risk Factors | United States/ep [Epidemiology]Institution(s): MedStar Health Research InstituteActivity type: Journal Article.Medline article type(s): Journal ArticleOnline resources: Click here to access onlineDigital Object Identifier: https://dx.doi.org/10.1016/j.amjcard.2019.02.012 (Click here)Abbreviated citation: Am J Cardiol. 123(10):1620-1625, 2019 May 15.Local Holdings: Available online from MWHC library: 1995 - present, Available in print through MWHC library: 1999 - 2006.Abstract: Copyright (c) 2019 Elsevier Inc. All rights reserved.Abstract: Women with history of pregnancy loss (PL) have higher burden of cardiovascular disease (CVD) later in life, yet it is unclear whether this is attributable to an association with established CVD risk factors (RFs). We examined whether PL is associated with CVD RFs and biomarkers in parous postmenopausal women in the Women's Health Initiative, and whether the association between PL and CVD RFs accounted for the association between PL and incident CVD. Linear and logistic regressions were used to estimate associations between baseline history of PL and CVD RFs. Cox proportional hazards regression models were used to estimate the associations between baseline history of PL and incident CVD after adjustment for baseline RFs. Of 79,121 women, 27,272 (35%) had experienced PL. History of PL was associated with higher body mass index (p < 0.0001), hypertension (p < 0.0001), diabetes (p=0.003), depression (p < 0.0001), and lower income (p < 0.0001), physical activity (p=0.01), poorer diet (p < 0.0001), smoking (p < 0.0001), and alcohol use (p < 0.0001). After adjustment for CVD RFs, PL was significantly associated with incident CVD over mean follow up of 16 years (hazard ratio 1.11, 95% confidence interval 1.06 to 1.16). In conclusion, several CVD RFs are associated with PL, but they do not entirely account for the association between PL and incident CVD.