Citation: Circulation Journal. 2019 May 22.Journal: Circulation journal : official journal of the Japanese Circulation Society.Published: ; 2019ISSN: 1346-9843.Full author list: Ozaki Y; Garcia-Garcia HM; Beyene SS; Hideo-Kajita A; Kuku KO; Kolm P; Waksman R.UI/PMID: 31118354.Subject(s): IN PROCESS -- NOT YET INDEXEDInstitution(s): MedStar Heart & Vascular InstituteActivity type: Journal Article.Medline article type(s): Journal ArticleDigital Object Identifier: https://dx.doi.org/10.1253/circj.CJ-18-1376 (Click here)Abbreviated citation: Circ J. 2019 May 22.Abstract: BACKGROUND: Statin therapy has been shown to result in coronary plaque regression, but the relationship between statin use and stabilization of coronary plaque has not been elucidated. We conducted a systematic review and meta-analysis to evaluate the effect of statin therapy on fibrous cap thickness (FCT) on optical coherence tomography (OCT).Methods and Results:Nine OCT studies (6 randomized controlled trials and 3 observational studies) were enrolled with a total of 341 patients (390 lesions). Arms of the studies were grouped according to statin type and/or dose. Random effects meta-analysis was used to estimate a pooled mean change in FCT from baseline to follow-up. The overall effect mean FCT change was 67.7 micro m (95% CI: 51.4-84.1, I<sup>2</sup>=95.0%, P<0.001). All statin groups had an increase in FCT, but the magnitude of the increase differed according to the statin. Two homogeneous subgroups with I<sup>2</sup>=0 were identified: mean FCT change was 27.8 micro m (for subgroup atorvastatin 5 mg and rosuvastatin), and 61.9 micro m (for subgroup atorvastatin 20 mg, fluvastatin 30 mg, and pitavastatin 4 mg). On meta-regression modeling, statin therapy alone explained most of the change in FCT.Abstract: CONCLUSIONS: Statin therapy induced a significant increase in FCT as assessed on OCT, independent of coronary risk factors and other medications.