Therapeutic Application of Cannabis in Medicine and Its Relevance to Thoracic Surgery. [Review]
Citation: Annals of Thoracic Surgery. 112(2):665-671, 2021 08.PMID: 33248994Institution: MedStar Washington Hospital CenterDepartment: Medicine/Pulmonary-Critical Care | MedStar General Surgery Residency | Surgery/Thoracic SurgeryForm of publication: Journal ArticleMedline article type(s): Journal Article | ReviewSubject headings: *Analgesics/tu [Therapeutic Use] | *Cannabis | *Pain, Postoperative/th [Therapy] | *Thoracic Surgical Procedures | HumansYear: 2021Local holdings: Available online from MWHC library: 1995 - present, Available in print through MWHC library:1999-2007Abstract: BACKGROUND: Cannabis is the most commonly used illicit substance in the United States. As cannabis use rises in popularity and its legalization continues to expand, the scientific community must address the controversy between beneficial and adverse effects of cannabis consumption.CONCLUSIONS: We acknowledge that additional studies are required to elucidate the long-term effects of cannabis products and that many potential biases and limitations exist in the literature due to self-reporting and limited survey studies. Appropriate stewardship over cannabis use among our patient population will likely determine its full implications in both oncologic and perioperative outcomes. Copyright (c) 2021 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.METHODS: We performed a comprehensive literature review to study the medicinal and pathologic effects of cannabis use, with emphasis on its association with cancer pathophysiology and thoracic surgery.RESULTS: We found evidence that cannabis products often contain carcinogenic materials and that their use is associated with the development of certain head and neck cancers, but not lung cancer. Indeed, several in vitro and in vivo studies have demonstrated that cannabis may have a therapeutic role in cancer given the antiproliferative effects of its active compounds such as delta-9-tetrahydrocannabinol. Cannabis-derived products have also been shown to be effective treatments for chronic pain, neuropathy, spasticity, and as antiemetics.Originally published: Annals of Thoracic Surgery. 2020 Nov 26Fiscal year: FY2022Fiscal year of original publication: FY2021Digital Object Identifier: Date added to catalog: 2021-07-26| Item type | Current library | Collection | Call number | Status | Date due | Barcode |
|---|---|---|---|---|---|---|
| Journal Article | MedStar Authors Catalog | Article | 33248994 | Available | 33248994 |
Available online from MWHC library: 1995 - present, Available in print through MWHC library:1999-2007
BACKGROUND: Cannabis is the most commonly used illicit substance in the United States. As cannabis use rises in popularity and its legalization continues to expand, the scientific community must address the controversy between beneficial and adverse effects of cannabis consumption.
CONCLUSIONS: We acknowledge that additional studies are required to elucidate the long-term effects of cannabis products and that many potential biases and limitations exist in the literature due to self-reporting and limited survey studies. Appropriate stewardship over cannabis use among our patient population will likely determine its full implications in both oncologic and perioperative outcomes. Copyright (c) 2021 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.
METHODS: We performed a comprehensive literature review to study the medicinal and pathologic effects of cannabis use, with emphasis on its association with cancer pathophysiology and thoracic surgery.
RESULTS: We found evidence that cannabis products often contain carcinogenic materials and that their use is associated with the development of certain head and neck cancers, but not lung cancer. Indeed, several in vitro and in vivo studies have demonstrated that cannabis may have a therapeutic role in cancer given the antiproliferative effects of its active compounds such as delta-9-tetrahydrocannabinol. Cannabis-derived products have also been shown to be effective treatments for chronic pain, neuropathy, spasticity, and as antiemetics.
English