Comparison of Quantitative Flow Ratio and Invasive Physiology Indices in a Diverse Population at a Tertiary United States Hospital.
Citation: Cardiovascular Revascularization Medicine. 32:1-4, 2021 11.PMID: 34215559Institution: MedStar Heart & Vascular InstituteForm of publication: Journal ArticleMedline article type(s): Journal ArticleSubject headings: *Coronary Stenosis | *Fractional Flow Reserve, Myocardial | Coronary Angiography | Coronary Stenosis/dg [Diagnostic Imaging] | Coronary Vessels/dg [Diagnostic Imaging] | Hospitals | Humans | Predictive Value of Tests | Reproducibility of Results | Severity of Illness Index | United StatesYear: 2021Local holdings: Available in print through MWHC library: 2002 - presentAbstract: BACKGROUND: Quantitative flow ratio (QFR) is a technology to evaluate the coronary stenosis significance on 3-dimensional quantitative coronary angiography. The aim of this study is to evaluate and compare the QFR versus fractional flow reserve (FFR) and/or instantaneous free-wave ratio (iFR) in a US population with a fair African American population representation.CONCLUSIONS: In a US based representative population, vessel QFR accuracy and agreement with FFR as reference is high. Diagnostic performance of QFR in African Americans is also excellent. Copyright (c) 2021 Elsevier Inc. All rights reserved.METHODS AND RESULTS: This was a retrospective, observational and single center study which enrolled 100 patients who underwent coronary angiography. The diagnostic performance of QFR in terms of sensitivity was 0.80 (95%CI 0.64-0.97) and specificity was 0.95 (95%CI 0.90-1.00), the positive predictive value (PPV) was 0.83 (0.68-0.98), while the NPV was 0.94 (0.88-0.99). The overall accuracy was 0.91 and area under curve (AUC) was 0.92 (95% CI 0.87-0.97). The R-squared was 0.54 and the Bland-Altman plot showed a bias of 0.0016 (SD 0.063) and limits of agreement (LOA): Upper LOA 0.13 and Lower LOA -0.12. In African Americans (n=33), accuracy, AUC, sensitivity, specificity (94%; 0.90 (0.80-1.00); 0.90 (0.71-1.00); 0.96 (0.87-1.00), respectively) were better than those for the overall population.Originally published: Cardiovascular Revascularization Medicine. 2021 Jun 25Fiscal year: FY2022Fiscal year of original publication: FY2021Digital Object Identifier: Date added to catalog: 2021-07-26| Item type | Current library | Collection | Call number | Status | Date due | Barcode |
|---|---|---|---|---|---|---|
| Journal Article | MedStar Authors Catalog | Article | 34215559 | Available | 34215559 |
Available in print through MWHC library: 2002 - present
BACKGROUND: Quantitative flow ratio (QFR) is a technology to evaluate the coronary stenosis significance on 3-dimensional quantitative coronary angiography. The aim of this study is to evaluate and compare the QFR versus fractional flow reserve (FFR) and/or instantaneous free-wave ratio (iFR) in a US population with a fair African American population representation.
CONCLUSIONS: In a US based representative population, vessel QFR accuracy and agreement with FFR as reference is high. Diagnostic performance of QFR in African Americans is also excellent. Copyright (c) 2021 Elsevier Inc. All rights reserved.
METHODS AND RESULTS: This was a retrospective, observational and single center study which enrolled 100 patients who underwent coronary angiography. The diagnostic performance of QFR in terms of sensitivity was 0.80 (95%CI 0.64-0.97) and specificity was 0.95 (95%CI 0.90-1.00), the positive predictive value (PPV) was 0.83 (0.68-0.98), while the NPV was 0.94 (0.88-0.99). The overall accuracy was 0.91 and area under curve (AUC) was 0.92 (95% CI 0.87-0.97). The R-squared was 0.54 and the Bland-Altman plot showed a bias of 0.0016 (SD 0.063) and limits of agreement (LOA): Upper LOA 0.13 and Lower LOA -0.12. In African Americans (n=33), accuracy, AUC, sensitivity, specificity (94%; 0.90 (0.80-1.00); 0.90 (0.71-1.00); 0.96 (0.87-1.00), respectively) were better than those for the overall population.
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