Dermatologic manifestations of COVID-19-associated multisystem inflammatory syndrome in children. [Review]
Citation: Clinics in Dermatology. 39(2):329-333, 2021 Mar-Apr.PMID: 34272031Institution: MedStar Washington Hospital CenterDepartment: Dermatology | Medical Dermatology ResidencyForm of publication: Journal ArticleMedline article type(s): Journal ArticleSubject headings: *COVID-19/co [Complications] | *Skin Diseases/et [Etiology] | *Systemic Inflammatory Response Syndrome/co [Complications] | Child | COVID-19/di [Diagnosis] | Humans | Retrospective Studies | Systemic Inflammatory Response Syndrome/di [Diagnosis]Year: 2021Local holdings: Available online through MWHC library: 1995 - 2010, Available in print through MWHC library: 1999 - presentAbstract: Multisystem inflammatory syndrome in children (MIS-C) affects a small percentage of pediatric patients infected with COVID-19 and is characterized by fever, laboratory evidence of inflammation, multisystem involvement, and severe illness necessitating hospitalization. Skin findings are often present in these patients, and when initially compared with Kawasaki disease, they likely represent distinct phenomena and overall remain poorly characterized. In this retrospective review of 34 case reports and series, we identified cutaneous manifestations documented in 417 of 736 patients (57%) with MIS-C associated with COVID-19. "Rash" was the sole descriptor of skin findings in nearly half of patients. Case reports and smaller case series provided more detail, outlining a broad range of lesion morphologies (polymorphic, maculopapular, morbilliform, erythrodermic, urticarial, reticular, petechial, purpuric) in variable anatomic distribution. More thorough descriptions of dermatologic manifestations in patients with MIS-C are warranted to better characterize this syndrome, as they may lend important insight into pathogenic mechanisms of disease. Copyright (c) 2020 Elsevier Ltd. All rights reserved.Originally published: Clinics in Dermatology. 39(2):329-333, 2021 Mar-Apr.Fiscal year: FY2021Digital Object Identifier: Date added to catalog: 2021-07-26| Item type | Current library | Collection | Call number | Status | Date due | Barcode |
|---|---|---|---|---|---|---|
| Journal Article | MedStar Authors Catalog | Article | 34272031 | Available | 34272031 |
Available online through MWHC library: 1995 - 2010, Available in print through MWHC library: 1999 - present
Multisystem inflammatory syndrome in children (MIS-C) affects a small percentage of pediatric patients infected with COVID-19 and is characterized by fever, laboratory evidence of inflammation, multisystem involvement, and severe illness necessitating hospitalization. Skin findings are often present in these patients, and when initially compared with Kawasaki disease, they likely represent distinct phenomena and overall remain poorly characterized. In this retrospective review of 34 case reports and series, we identified cutaneous manifestations documented in 417 of 736 patients (57%) with MIS-C associated with COVID-19. "Rash" was the sole descriptor of skin findings in nearly half of patients. Case reports and smaller case series provided more detail, outlining a broad range of lesion morphologies (polymorphic, maculopapular, morbilliform, erythrodermic, urticarial, reticular, petechial, purpuric) in variable anatomic distribution. More thorough descriptions of dermatologic manifestations in patients with MIS-C are warranted to better characterize this syndrome, as they may lend important insight into pathogenic mechanisms of disease. Copyright (c) 2020 Elsevier Ltd. All rights reserved.
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