Citation: BMC Public Health. 19(1):591, 2019 May 17..Journal: BMC public health.Published: ; 2019ISSN: 1471-2458.Full author list: Zilberberg MD; Harrington R; Spalding JR; Shorr AF.UI/PMID: 31101036.Subject(s): Adolescent | Adult | Aged | *Aspergillosis/ep [Epidemiology] | *Cost of Illness | Female | *Hospitalization/sn [Statistics & Numerical Data] | Humans | Incidence | International Classification of Diseases | Male | Middle Aged | United States/ep [Epidemiology] | Young AdultInstitution(s): MedStar Washington Hospital CenterDepartment(s): Medicine/Pulmonary-Critical CareActivity type: Journal Article.Medline article type(s): Journal ArticleOnline resources: Click here to access onlineDigital Object Identifier: https://dx.doi.org/10.1186/s12889-019-6932-9 (Click here)Abbreviated citation: BMC Public Health. 19(1):591, 2019 May 17.Abstract: BACKGROUND: Using aggregated data available on the interactive website from the Agency for Healthcare Research and Quality's Healthcare Cost and Utilization Project Network (HCUPnet), we examined the annual volume of invasive aspergillosis (IA)-related hospitalizations in the US.Abstract: METHODS: This was a population study. Age-adjusted volumes were derived through population incidence calculated using year-specific censal and intercensal US population estimates available from the US Census Bureau. We additionally examined IA as the principal diagnosis and its associated outcomes in patients with ICD-9-CM codes 117.3, 117.9 and 484.6.Abstract: RESULTS: The age-adjusted number of annual hospitalizations with IA grew from 35,968 cases in 2004 to 51,870 in 2013, a 44.2% overall increase, 4.4% per annum. Regionally, the South contributed the plurality of the cases (40%), and the Northeast the fewest (17%). While IA as principal diagnosis dropped, from 14.4 to 9.3%, mortality rose from 10 to 12%. Despite mean hospital length of stay decreasing from 13.3 (standard error [SE] 0.07) to 11.5 (SE 0.6) days, the corresponding mean hospital charges rose from Abstract: CONCLUSIONS: Given the substantial volume and rate of growth in IA-related hospitalizations in the US between 2004 and 2013, an increase in mortality and high costs, IA may represent an attractive target for intensive preventive efforts.