A Gut Feeling: Acute Liver Failure - An Unusual Manifestation of Malignant Catatonia.

MedStar author(s):
Citation: Cureus. 13(5):e15242, 2021 May 25.PMID: 34188984Institution: MedStar Washington Hospital CenterDepartment: Internal Medicine ResidencyForm of publication: Journal ArticleMedline article type(s): Case ReportsSubject headings: IN PROCESS -- NOT YET INDEXEDYear: 2021Name of journal: CureusAbstract: We present a rare case in which malignant catatonia led to acute liver failure (ALF). A 19-year-old male was admitted for psychosis and developed ALF with a peak aspartate aminotransferase and alanine aminotransferase of 5,728 U/L and 7,735 U/L, respectively, and a peak international normalized ratio of 7.1. Liver biopsy showed significant confluent necrosis involving >70% of the liver tissue. He was listed for a liver transplant but was ultimately taken off of because of significant improvement with treatment by N-acetylcysteine infusion. Through our research, we found that symptoms of hepatitis can be seen with psychotic disorders, but ALF is rare. Copyright (c) 2021, Kiparizoska et al.All authors: Davis W, Duong M, Griffith N, Hsu C, Kiparizoska SFiscal year: FY2021Digital Object Identifier: Date added to catalog: 2021-07-26
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Journal Article MedStar Authors Catalog Article 34188984 Available 34188984

We present a rare case in which malignant catatonia led to acute liver failure (ALF). A 19-year-old male was admitted for psychosis and developed ALF with a peak aspartate aminotransferase and alanine aminotransferase of 5,728 U/L and 7,735 U/L, respectively, and a peak international normalized ratio of 7.1. Liver biopsy showed significant confluent necrosis involving >70% of the liver tissue. He was listed for a liver transplant but was ultimately taken off of because of significant improvement with treatment by N-acetylcysteine infusion. Through our research, we found that symptoms of hepatitis can be seen with psychotic disorders, but ALF is rare. Copyright (c) 2021, Kiparizoska et al.

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