Eosinophilic Myocarditis: When Allergies Attack the Heart!.

MedStar author(s):
Citation: Cardiology in Review. 30(2):70-74, 2022 Mar-Apr 01.PMID: 34369408Institution: MedStar Heart & Vascular InstituteForm of publication: Journal ArticleMedline article type(s): Journal ArticleSubject headings: *Hypereosinophilic Syndrome | *Hypersensitivity | *Myocarditis | Heart | Humans | Hypereosinophilic Syndrome/di [Diagnosis] | Hypereosinophilic Syndrome/dt [Drug Therapy] | Myocarditis/di [Diagnosis] | Myocarditis/et [Etiology] | MyocardiumYear: 2022ISSN:
  • 1061-5377
Name of journal: Cardiology in reviewAbstract: Eosinophilic myocarditis is a clinical condition whereby myocardial injury is mediated by eosinophilic infiltration. A number of underlying causes, including reactive, clonal or idiopathic hypereosinophilic syndrome, may trigger eosinophilia. Disease presentation may vary from mild sub-clinical variants to fulminant myocarditis with thromboembolic complications, and in some cases, endomyocardial and valvular fibrosis may be seen. A detailed examination coupled with the use of multimodality imaging and endomyocardial biopsy may help establish diagnosis. Treatment is aimed at symptomatic management and treating the underlying cause of eosinophilia, such as withdrawal of implicated drugs, anti-helminthic therapy for infection, immunosuppression for autoimmune conditions, and targeted therapy with tyrosine kinase inhibitors in cases with clonal myeloid disorders. Copyright (c) 2021 Wolters Kluwer Health, Inc. All rights reserved.All authors: Aggarwal D, Aronow WS, Bandopadhyay D, Bansal A, Barzilai B, Bhatia K, Chetrit M, Doshi R, Frishman WH, Ghosh R, Gupta M, Jain V, Shiau CJ, Thakkar SOriginally published: Cardiology in Review. 2021 Aug 04Fiscal year: FY2022Fiscal year of original publication: FY2022Digital Object Identifier: Date added to catalog: 2021-11-01
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Journal Article MedStar Authors Catalog Article 34369408 Available 34369408

Eosinophilic myocarditis is a clinical condition whereby myocardial injury is mediated by eosinophilic infiltration. A number of underlying causes, including reactive, clonal or idiopathic hypereosinophilic syndrome, may trigger eosinophilia. Disease presentation may vary from mild sub-clinical variants to fulminant myocarditis with thromboembolic complications, and in some cases, endomyocardial and valvular fibrosis may be seen. A detailed examination coupled with the use of multimodality imaging and endomyocardial biopsy may help establish diagnosis. Treatment is aimed at symptomatic management and treating the underlying cause of eosinophilia, such as withdrawal of implicated drugs, anti-helminthic therapy for infection, immunosuppression for autoimmune conditions, and targeted therapy with tyrosine kinase inhibitors in cases with clonal myeloid disorders. Copyright (c) 2021 Wolters Kluwer Health, Inc. All rights reserved.

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