MedStar Authors catalog › Details for: Mild gestational diabetes mellitus and long-term child health.
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Mild gestational diabetes mellitus and long-term child health.

by Reddy, Uma M.
Citation: Diabetes Care. 38(3):445-52, 2015 Mar..Journal: Diabetes care.ISSN: 0149-5992.Full author list: Landon MB; Rice MM; Varner MW; Casey BM; Reddy UM; Wapner RJ; Rouse DJ; Biggio JR Jr; Thorp JM; Chien EK; Saade G; Peaceman AM; Blackwell SC; VanDorsten JP; Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units (MFMU) Network.UI/PMID: 25414152.Subject(s): Adult | Body Mass Index | Body Weight | Child | Cholesterol, HDL/bl [Blood] | Diabetes, Gestational/bl [Blood] | Diabetes, Gestational/pp [Physiopathology] | *Diabetes, Gestational/th [Therapy] | Fasting | Female | Follow-Up Studies | Health Status | Humans | Insulin/bl [Blood] | Insulin Resistance/ph [Physiology] | Male | *Obesity/pc [Prevention & Control] | Pregnancy | Prenatal Care | *Prenatal Exposure Delayed Effects/pc [Prevention & Control] | Sex Factors | Triglycerides/bl [Blood] | Waist CircumferenceInstitution(s): MedStar Washington Hospital CenterDepartment(s): Obstetrics and Gynecology, Maternal-Fetal MedicineActivity type: Journal Article.Medline article type(s): Journal Article | Multicenter Study | Randomized Controlled Trial | Research Support, N.I.H., ExtramuralOnline resources: Click here to access online Digital Object Identifier: http://dx.doi.org/10.2337/dc14-2159 (Click here) Abbreviated citation: Diabetes Care. 38(3):445-52, 2015 Mar.Local Holdings: Available online from MWHC library: 1995 - present, Available in print through MWHC library: 1999 - 2006.Abstract: OBJECTIVE: To evaluate whether treatment of mild gestational diabetes mellitus (GDM) confers sustained offspring health benefits, including a lower frequency of obesity.Abstract: RESEARCH DESIGN AND METHODS: Follow-up study of children (ages 5-10) of women enrolled in a multicenter trial of treatment versus no treatment of mild GDM. Height, weight, blood pressure, waist circumference, fasting glucose, fasting insulin, triglycerides, and HDL cholesterol were measured.Abstract: RESULTS: Five hundred of 905 eligible offspring (55%) were enrolled. Maternal baseline characteristics were similar between the follow-up treated and untreated groups. The frequencies of BMI >95th (20.8% and 22.9%) and 85th (32.6% and 38.6%) percentiles were not significantly different in treated versus untreated offspring (P = 0.69 and P = 0.26). No associations were observed for BMI z score, log waist circumference, log triglycerides, HDL cholesterol, blood pressure, or log HOMA-estimated insulin resistance (HOMA-IR). The effect of treatment was different by sex for fasting glucose and log HOMA-IR (P for interaction = 0.002 and 0.02, respectively) but not by age-group (5-6 and 7-10 years) for any outcomes. Female offspring of treated women had significantly lower fasting glucose levels.Abstract: CONCLUSIONS: Although treatment for mild GDM has been associated with neonatal benefits, no reduction in childhood obesity or metabolic dysfunction in the offspring of treated women was found. However, only female offspring of women treated for mild GDM had lower fasting glucose.Copyright � 2015 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered.

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