MedStar Authors catalog › Details for: Antenatal Magnesium and Cerebral Palsy in Preterm Infants.
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Antenatal Magnesium and Cerebral Palsy in Preterm Infants.

by Reddy, Uma M.
Citation: Journal of Pediatrics. 167(4):834-839.e3, 2015 Oct..Journal: The Journal of pediatrics.ISSN: 1097-6833.Full author list: Hirtz DG; Weiner SJ; Bulas D; DiPietro M; Seibert J; Rouse DJ; Mercer BM; Varner MW; Reddy UM; Iams JD; Wapner RJ; Sorokin Y; Thorp JM Jr; Ramin SM; Malone FD; Carpenter MW; O'Sullivan MJ; Peaceman AM; Hankins GD; Dudley D; Caritis SN; Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network.UI/PMID: 26254839.Subject(s): Cerebral Hemorrhage/us [Ultrasonography] | *Cerebral Palsy/bl [Blood] | Cerebral Palsy/pc [Prevention & Control] | *Cerebral Palsy/us [Ultrasonography] | Cerebral Ventricles/us [Ultrasonography] | Child, Preschool | Cohort Studies | Electroencephalography | Female | Gestational Age | Humans | Infant | Infant, Newborn | Infant, Premature | Leukomalacia, Periventricular/us [Ultrasonography] | *Magnesium Sulfate/tu [Therapeutic Use] | Male | Maternal Exposure | Neuroprotective Agents/tu [Therapeutic Use] | PregnancyInstitution(s): MedStar Washington Hospital CenterDepartment(s): Obstetrics and Gynecology, Maternal-Fetal MedicineActivity type: Journal Article.Medline article type(s): Journal Article | Randomized Controlled Trial | Research Support, N.I.H., ExtramuralOnline resources: Click here to access online Digital Object Identifier: http://dx.doi.org/10.1016/j.jpeds.2015.06.067 (Click here) Abbreviated citation: J Pediatr. 167(4):834-839.e3, 2015 Oct.Local Holdings: Available online from MWHC library: 1995 - present.Abstract: OBJECTIVE: To evaluate the relationship of maternal antenatal magnesium sulfate (MgSO4) with neonatal cranial ultrasound abnormalities and cerebral palsy (CP).Abstract: STUDY DESIGN: In a randomized trial of MgSO4 or placebo in women at high risk of preterm delivery, up to 3 cranial ultrasounds were obtained in the neonatal period. Images were reviewed by at least 2 pediatric radiologists masked to treatment and other clinical conditions. Diagnoses were predefined for intraventricular hemorrhage, periventricular leukomalacia, intracerebral echolucency or echodensity, and ventriculomegaly. CP was diagnosed at 2 years of age by standardized neurologic examination.Abstract: RESULTS: Intraventricular hemorrhage, periventricular leukomalacia, intracerebral echolucency or echodensity, and ventriculomegaly were all strongly associated with an increased risk of CP. MgSO4 administration did not affect the risk of cranial ultrasound abnormality observed at 35 weeks postmenstrual age or later. However, for the 82% of infants born at <32 weeks gestation, MgSO4 was associated with a reduction in risk of echolucency or echodensity. The reduction in risk for echolucency explained 21% of the effect of MgSO4 on CP (P = .04), and for echodensity explained 20% of the effect (P = .02).Abstract: CONCLUSIONS: MgSO4 given prior to preterm delivery was associated with decreased risk of developing echodensities and echolucencies at <32 weeks gestation. However, this effect can only partially explain the effect of MgSO4 on CP at 2 years of age.Abstract: TRIAL REGISTRATION: ClinicalTrials.gov: NCT00014989.Copyright Published by Elsevier Inc.

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