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Outcome of percutaneous coronary intervention utilizing drug-eluting stents in patients with reduced left ventricular ejection fraction.

by Sardi, Gabriel L; Gaglia, Michael AJ; Maluenda, Gabriel; Torguson, Rebecca; Laynez-Carnicero, Ana; Ben-Dor, Itsik; Hauville, Camille; Xue, Zhenyi; Suddath, William O; Kent, Kenneth M; Satler, Lowell F; Pichard, Augusto D; Lindsay, Joseph; Waksman, Ron.
Citation: American Journal of Cardiology. 109(3):344-51, 2012 Feb 1..Journal: The American journal of cardiology.ISSN: 0002-9149.Full author list: Sardi GL; Gaglia MA Jr; Maluenda G; Torguson R; Laynez-Carnicero A; Ben-Dor I; Hauville C; Xue Z; Suddath WO; Kent KM; Satler LF; Pichard AD; Lindsay J; Waksman R.UI/PMID: 22112742.Subject(s): Aged | *Angioplasty, Balloon, Coronary/mt [Methods] | Cause of Death/td [Trends] | Coronary Angiography | District of Columbia/ep [Epidemiology] | *Drug-Eluting Stents | Echocardiography | Electrocardiography | Female | Follow-Up Studies | Gated Blood-Pool Imaging | Humans | Male | Middle Aged | Myocardial Ischemia/co [Complications] | Myocardial Ischemia/mo [Mortality] | *Myocardial Ischemia/su [Surgery] | Prognosis | Retrospective Studies | Risk Factors | *Stroke Volume | Survival Rate/td [Trends] | Treatment Outcome | *Ventricular Dysfunction, Left/co [Complications] | Ventricular Dysfunction, Left/mo [Mortality] | Ventricular Dysfunction, Left/pp [Physiopathology]Institution(s): MedStar Heart & Vascular Institute | MedStar Health Research InstituteActivity type: Journal Article.Medline article type(s): Comparative Study | Journal ArticleOnline resources: Click here to access online Digital Object Identifier: http://dx.doi.org/10.1016/j.amjcard.2011.09.016 (Click here) Abbreviated citation: Am J Cardiol. 109(3):344-51, 2012 Feb 1.Local Holdings: Available online from MWHC library: 1995 - present, Available in print through MWHC library: 1999 - 2006.Abstract: Ischemic cardiomyopathy with depressed left ventricular ejection fraction (LVEF) is predictive of death after percutaneous coronary intervention (PCI), but its association with stent thrombosis (ST) and the need for repeat revascularization is less clearly defined. In total 5,377 patients undergoing PCI were retrospectively evaluated. Multivariable Cox proportional hazards regression and competitive outcome analysis were employed. The primary end point was 1-year major adverse cardiac events (all-cause death, Q-wave myocardial infarction, ST, and target lesion revascularization [TLR]). Individual end points of ST and of TLR were also evaluated. Patients with normal LVEF (>50%) were compared to those with mild (41% to 50%), moderate (25% to 40%), and severe (<25%) decreases in LVEF. Patients with abnormal LVEF were older and more commonly diabetic and had renal insufficiency and heart failure syndrome (p <0.001 for all variables). These patients demonstrated more angiographically complex lesions and less frequently received a drug-eluting stent. The primary end point was significantly increased in patients with lower LVEF (9.7% for normal LVEF vs 20.6% for severely decreased LVEF, p <0.001). ST occurred more frequently in these patients (1.4% for normal LVEF vs 6% for severely decreased LVEF, p <0.001), but clinically driven TLR did not significantly 130912 across LVEF categories. After adjustment, only moderate and severe LVEF decreases (i.e., LVEF <=40%) demonstrated an association with major adverse cardiac events and with the individual outcome of ST. Subgroup analysis of patients receiving only a drug-eluting stent or a bare-metal stent demonstrated no statistically significant differences for the probability of ST. In conclusion, decreased LVEF is not associated with clinically driven TLR but does increase the risk of ST. Patients with LVEF <=40% appear to be at significantly higher risk for ST and therefore might benefit from interventional and pharmacologic strategies aimed at minimizing this risk. Copyright 2012 Elsevier Inc. All rights reserved.

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