MedStar Authors catalog › Details for: Association of chronic kidney disease with cerebral microbleeds in patients with primary intracerebral hemorrhage.
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Association of chronic kidney disease with cerebral microbleeds in patients with primary intracerebral hemorrhage.

by Shara, Nawar M; Fernandez, Stephen J; Kidwell, Chelsea S.
Citation: Stroke. 44(9):2409-13, 2013 Sep..ISSN: 0039-2499.Full author list: Ovbiagele B; Wing JJ; Menon RS; Burgess RE; Gibbons MC; Sobotka I; German L; Shara NM; Fernandez S; Jayam-Trouth A; Edwards DF; Kidwell CS.UI/PMID: 23847251.Subject(s): African Continental Ancestry Group/eh [Ethnology] | Aged | Cerebral Hemorrhage/co [Complications] | *Cerebral Hemorrhage/ep [Epidemiology] | Cerebral Hemorrhage/pp [Physiopathology] | Comorbidity | District of Columbia/ep [Epidemiology] | District of Columbia/eh [Ethnology] | European Continental Ancestry Group/eh [Ethnology] | Female | Glomerular Filtration Rate/ph [Physiology] | Humans | Male | Middle Aged | Renal Insufficiency, Chronic/co [Complications] | *Renal Insufficiency, Chronic/ep [Epidemiology] | Renal Insufficiency, Chronic/pp [Physiopathology] | Retrospective Studies | RiskInstitution(s): MedStar Health Research Institute | MedStar Heart & Vascular InstituteActivity type: Journal Article.Medline article type(s): Comparative Study | Journal Article | Multicenter Study | Research Support, N.I.H., ExtramuralOnline resources: Click here to access online Digital Object Identifier: http://dx.doi.org/10.1161/STROKEAHA.113.001958 (Click here) Abbreviated citation: Stroke. 44(9):2409-13, 2013 Sep.Local Holdings: Available online from MWHC library: 1970 - present, Available in print through MWHC library: 1999 - 2006.Abstract: BACKGROUND AND PURPOSE: To investigate the relationship between chronic kidney disease (CKD) and MRI-defined cerebral microbleeds (CMB), a harbinger of future intracerebral hemorrhage (ICH), among patients with a recent history of primary ICH.Abstract: METHODS: Using data from a predominantly black cohort of patients with a recent ICH-enrolled in an observational study between September 2007 and June 2011, we evaluated the association between CKD (defined as estimated low glomerular filtration rate<60 mL/min per 1.73 m(2)) and CMB on gradient-echo MRI. Multivariable models were generated to determine the contribution of CKD to the presence, number, and location of CMB.Abstract: RESULTS: Of 197 subjects with imaging data, mean age was 59 years, 48% were women, 73% were black, 114 (58%) had >=1 CMBs, and 52 (26%) had CKD. Overall, CKD was associated with presence of CMB (adjusted odds ratio, 2.70; 95% confidence interval [CI], 1.10-6.59) and number of CMB (adjusted relative risk, 2.04; 95% CI, 1.27-3.27). CKD was associated with CMB presence (adjusted odds ratio, 3.44; 95% CI, 1.64-7.24) and number (adjusted relative risk, 2.46; 95% CI, 1.11-5.42) in black patients, but not CMB presence (adjusted odds ratio, 3.00; 95% CI, 0.61-14.86) or number (adjusted relative risk, 1.03; 95% CI: 0.22-4.89) in non-Hispanic white patients (interactions by race were statistically not significant).Abstract: CONCLUSIONS: CKD is associated with a greater presence and number of CMB in ICH patients, particularly in patients of black race. Future studies should assess whether low estimated glomerular filtration rate may be a CMB risk marker or potential therapeutic target for mitigating the development of CMB.

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