MedStar Authors catalog › Details for: Prevalence and prognostic significance of exercise-induced nonsustained ventricular tachycardia in asymptomatic volunteers: BLSA (Baltimore Longitudinal Study of Aging).
Prevalence and prognostic significance of exercise-induced nonsustained ventricular tachycardia in asymptomatic volunteers: BLSA (Baltimore Longitudinal Study of Aging). ISSN: 0735-1097. UI/PMID: 23747767. Subject(s): Adult | Age Factors | Aged | *Aging/ph [Physiology] | Baltimore | Confidence Intervals | Electrocardiography/mt [Methods] | *Exercise Test/ae [Adverse Effects] | Female | Geriatric Assessment/mt [Methods] | Human Experimentation | Humans | Kaplan-Meier Estimate | Longitudinal Studies | Male | Middle Aged | Multivariate Analysis | Prevalence | Proportional Hazards Models | Prospective Studies | Reference Values | Severity of Illness Index | Sex Factors | Survival Rate | Tachycardia, Ventricular/di [Diagnosis] | *Tachycardia, Ventricular/ep [Epidemiology] | *Tachycardia, Ventricular/et [Etiology] Institution(s): MedStar Health Research Institute | MedStar Heart & Vascular Institute Activity type: Journal Article. Medline article type(s): Comparative Study | Journal Article Online resources: Click here to access online Digital Object Identifier: http://dx.doi.org/10.1016/j.jacc.2013.05.026 (Click here) Abbreviated citation: J Am Coll Cardiol. 62(7):595-600, 2013 Aug 13. Local Holdings: Available online from MWHC library: 1995 - present, Available in print through MWHC library:1999-2007. Abstract: OBJECTIVES: This study sought to determine the clinical predictors and prognostic significance of exercise-induced nonsustained ventricular tachycardia (NSVT) in a large population of asymptomatic volunteers. Abstract: BACKGROUND: Prior studies have reported variable risk associated with exercise-induced ventricular arrhythmia. Abstract: METHODS: Subjects in the BLSA (Baltimore Longitudinal Study of Aging) free of known cardiovascular disease who completed at least 1 symptom-limited exercise treadmill test between 1977 and 2001 were included. NSVT episodes were characterized by QRS morphology, duration, and rate. Subjects underwent follow-up clinical evaluation every 2 years. Abstract: RESULTS: The 2,099 subjects (mean age: 52 years; 52.2% male) underwent a mean of 2.7 exercise tests, in which 79 (3.7%)developed NSVT with exercise on at least 1 test. The median duration of NSVT was 3 beats (<=5 beats in 84%), and the median rate was 175 beats/min. Subjects with (vs. without) NSVT were older (67 +/- 12 years vs. 51+/-17 years, p< 0.0001) and more likely to be male (80% vs. 51%, p< 0.0001) and to have baseline electrocardiographic abnormalities (50% vs. 17%, p< 0.0001) or ischemic ST-segment 131223s with exercise (20% vs. 10%, p= 0.004). Over a mean follow-up of 13.5 +/- 7.7 years, 518 deaths (24.6%) occurred. After multivariable adjustment for age, sex, and coronary risk factors, exercise-induced NSVT was not significantly associated with total mortality (hazard ratio: 1.30; 95% confidence interval: 0.89 to 1.90; p= 0.17).
Abstract: CONCLUSIONS: Exercise-induced NSVT occurred in nearly 4% of this asymptomatic adult cohort. This finding increased with age and was more common in men. After adjustment for clinical variables, exercise-induced NSVT did not independently increase the risk of total mortality. Copyright 2013 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.