A novel cause of emergent hyperammonemia: Cryptococcal fungemia and meningitis.

MedStar author(s):
Citation: Molecular Genetics and Metabolism Reports. 29:100825, 2021 Dec.PMID: 34900596Institution: MedStar Franklin Square Medical CenterDepartment: Internal MedicineForm of publication: Journal ArticleMedline article type(s): Case ReportsSubject headings: IN PROCESS -- NOT YET INDEXEDYear: 2021ISSN:
  • 2214-4269
Name of journal: Molecular genetics and metabolism reportsAbstract: Among etiologies of hyperammonemic emergencies, infection must be considered in certain clinical contexts, particularly among immunocompromised individuals. Although Cryptococcus neoformans is known to be urease-producing, to our knowledge it has not previously been described as a cause of hyperammonemia in patients. We report an immunocompromised man with acute on chronic kidney disease with hyperammonemic crisis due to Cryptococcal meningitis and fungemia. It is important to be aware of C. neoformans as a possible cause of hyperammonemia. Copyright (c) 2021 The Authors.All authors: Armitage KB, Dempsey KJ, Hannah WB, Konczal LL, McCandless SE, Nizialek GFiscal year: FY2022Digital Object Identifier: Date added to catalog: 2022-01-25
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Journal Article MedStar Authors Catalog Article 34900596 Available 34900596

Among etiologies of hyperammonemic emergencies, infection must be considered in certain clinical contexts, particularly among immunocompromised individuals. Although Cryptococcus neoformans is known to be urease-producing, to our knowledge it has not previously been described as a cause of hyperammonemia in patients. We report an immunocompromised man with acute on chronic kidney disease with hyperammonemic crisis due to Cryptococcal meningitis and fungemia. It is important to be aware of C. neoformans as a possible cause of hyperammonemia. Copyright (c) 2021 The Authors.

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