MedStar Authors catalog › Details for: Anatomical characteristics associated with hypoattenuated leaflet thickening in low-risk patients undergoing transcatheter aortic valve replacement.
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Anatomical characteristics associated with hypoattenuated leaflet thickening in low-risk patients undergoing transcatheter aortic valve replacement.

by Khan, Jaffar M; Rogers, Toby; Weissman, Gaby; Rodriguez-Weisson, Fernando J; Chezar-Azerrad, Chava; Gupta, Neha; Medvedofsky, Diego; Zhang, Cheng; Shults, Christian; Garcia-Garcia, Hector M; Kolm, Paul; Satler, Lowell F; Hashim, Hayder; Ben-Dor, Itsik; Asch, Federico M; Waksman, Ron.
Citation: Cardiovascular Revascularization Medicine. 2020 Sep 25.Journal: Cardiovascular revascularization medicine : including molecular interventions.Published: ; 2020ISSN: 1878-0938.Full author list: Khan JM; Rogers T; Weissman G; Torguson R; Rodriguez-Weisson FJ; Chezar-Azerrad C; Greenspun B; Gupta N; Medvedofsky D; Zhang C; Gordon P; Ehsan A; Wilson SR; Goncalves J; Levitt R; Hahn C; Parikh P; Bilfinger T; Butzel D; Buchanan S; Hanna N; Garrett R; Shults C; Buchbinder M; Garcia-Garcia HM; Kolm P; Satler LF; Hashim H; Ben-Dor I; Asch FM; Waksman R.UI/PMID: 33129688.Subject(s): IN PROCESS -- NOT YET INDEXEDInstitution(s): MedStar Heart & Vascular Institute | MedStar Health Research InstituteActivity type: Journal Article.Medline article type(s): Journal ArticleOnline resources: Click here to access online Digital Object Identifier: https://dx.doi.org/10.1016/j.carrev.2020.09.034 (Click here) Abbreviated citation: Cardiovasc Revasc Med. 2020 Sep 25.Local Holdings: Available in print through MWHC library: 2002 - present.Abstract: BACKGROUND/PURPOSE: This sub-analysis of the prospective Low Risk TAVR (LRT) trial determined anatomical characteristics associated with hypoattenuated leaflet thickening (HALT), which may contribute to early transcatheter heart valve (THV) degeneration.Abstract: METHODS/MATERIALS: The LRT trial enrolled 200 low-risk patients between February 2016 and February 2018. All subjects underwent baseline and 30-day CT studies, analyzed by an independent core laboratory. Additional measurements, namely THV expansion, eccentricity, depth, and commissural alignment, were made by consensus of three independent readers. HALT was observed only in the Sapien 3 THV, so Evolut valves were excluded from this analysis.Abstract: RESULTS: In the LRT trial, 177 subjects received Sapien 3 THVs, of whom 167 (94.3%) had interpretable 30-day CTs and were eligible for this analysis. Twenty-six subjects had HALT (15.6%). Baseline characteristics were similar between groups. There was no difference in THV size implanted and baseline aortic-root geometry between groups. In patients who developed HALT, THV implantation depth was shallower than in patients who did not develop HALT (2.6 +/- 1.1 mm HALT versus 3.3 +/- 1.8 mm no-HALT, p = 0.03). There were more patients in the HALT group with commissural malalignment (40% vs. 28%; p = 0.25), but this did not reach statistical significance. In a univariable regression model, no predetermined variables were shown to independently predict the development of HALT.Abstract: CONCLUSIONS: This study did not find anatomical or THV implantation characteristics that predicted the development of HALT at 30 days. This study cannot exclude subtle effects or interaction between factors because of the small number of events.Abstract: SUMMARY: This sub-analysis of the prospective Low Risk TAVR trial found that hypoattenuated leaflet thickening (HALT) was associated with shallower transcatheter heart valve implantation. No predictors of HALT were found in a univariable regression analysis. Copyright (c) 2020. Published by Elsevier Inc.

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