MedStar Authors catalog › Details for: In vivo comparison of a polymer-free Biolimus A9-eluting stent with a biodegradable polymer-based Biolimus A9 eluting stent and a bare metal stent in balloon denuded and radiated hypercholesterolemic rabbit iliac arteries.
In vivo comparison of a polymer-free Biolimus A9-eluting stent with a biodegradable polymer-based Biolimus A9 eluting stent and a bare metal stent in balloon denuded and radiated hypercholesterolemic rabbit iliac arteries. Journal: Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions. ISSN: 1522-1946. UI/PMID: 22105925. Subject(s): *Absorbable Implants | *Angioplasty, Balloon/is [Instrumentation] | Animals | Atherosclerosis/et [Etiology] | Atherosclerosis/me [Metabolism] | Atherosclerosis/pa [Pathology] | *Atherosclerosis/th [Therapy] | *Cardiovascular Agents/ad [Administration & Dosage] | Constriction, Pathologic | Disease Models, Animal | *Drug-Eluting Stents | Fibrin/me [Metabolism] | *Hypercholesterolemia/co [Complications] | Hyperplasia | Iliac Artery/me [Metabolism] | *Iliac Artery/pa [Pathology] | Iliac Artery/re [Radiation Effects] | Inflammation/pa [Pathology] | Male | *Metals | Neointima | Plaque, Atherosclerotic | *Polymers | Prosthesis Design | Rabbits | Sirolimus/ad [Administration & Dosage] | *Sirolimus/aa [Analogs & Derivatives] | *Stents | Time Factors Institution(s): MedStar Heart & Vascular Institute | MedStar Health Research Institute Activity type: Journal Article. Medline article type(s): Comparative Study | Journal Article Online resources: Click here to access online Digital Object Identifier: http://dx.doi.org/10.1002/ccd.2340 (Click here) Abbreviated citation: Catheter Cardiovasc Interv. 80(3):429-36, 2012 Sep 1. Local Holdings: Available online from MWHC library: 1996 - present, Available in print through MWHC library: 1996 - 2006. Abstract: OBJECTIVES: To evaluate the effect of a polymer-free Biolimus A9-eluting stent [BioFreedom (BF)], compared with that of a biodegradable polymer-based Biolimus A9-eluting stent [BioMatrix Flex (BMF)] and a bare metal stent (BMS) in balloon denuded and radiated hypercholesterolemic rabbit iliac arteries. Abstract: METHODS: Rabbits were fed with 1% cholesterol diet (n = 14) for 14 days, both iliac arteries were balloon denuded and radiated, and then rabbits were switched to 0.15% cholesterol diet. After 4 weeks, BF (n = 8), BMF (n = 8), and BMS (n = 8) were deployed in denuded and radiated areas. Four weeks later animals were euthanized, arterial segments were processed for morphometry. Abstract: RESULTS: The neointimal area in vessels implanted with BF stents was significantly less than that seen in vessels implanted with BMS (0.90 mm(2) +/- 0.14 vs. 1.29 mm(2) +/- 0.23, P <0.01). Percent fibrin and fibrin score were higher with BMF stents compared to BMS (P <0.03 and <0.04) and giant cell number was significantly higher with both BMF and BF stents (P < 0.01 for both). Percent endothelialization was significantly higher and % uncovered struts were lower with BMS compared to either BMF or BF stents (P < 0.05 for both).
Abstract: CONCLUSION: This study demonstrates that compared to BMS, BF stents significantly decreased neointimal hyperplasia. Copyright 2011 Wiley Periodicals, Inc.