Citation: World Journal of Gastrointestinal Endoscopy. 12(10):323-340, 2020 Oct 16..Journal: World journal of gastrointestinal endoscopy.Published: ; 2020Full author list: Yousaf MN; Ehsan H; Wahab A; Muneeb A; Chaudhary FS; Williams R; Haas CJ.UI/PMID: 33133370.Subject(s): IN PROCESS -- NOT YET INDEXEDInstitution(s): MedStar Union Memorial Hospital | MedStar Harbor HospitalDepartment(s): MedicineActivity type: Journal Article.Medline article type(s): Journal Article | ReviewOnline resources: Click here to access onlineDigital Object Identifier: https://dx.doi.org/10.4253/wjge.v12.i10.323 (Click here)Abbreviated citation: World J Gastrointest Endosc. 12(10):323-340, 2020 Oct 16.Abstract: Pancreatic cancer is the leading cause of cancer-related morbidity and mortality with an overall five-year survival of less than 9% in the United States. At presentation, the majority of patients have painless jaundice, pruritis, and malaise, a triad that develops secondary to obstruction, which often occurs late in the course of the disease process. The technical advancements in radiological imaging and endoscopic interventions have played a crucial role in the diagnosis, staging, and management of patients with pancreatic cancer. Endoscopic retrograde cholangiopancreatography (ERCP)-guided diagnosis (with brush cytology, serial pancreatic juice aspiration cytologic examination technique, or biliary biopsy) and therapeutic interventions such as pancreatobiliary decompression, intraductal and relief of gastric outlet obstruction play a pivotal role in the management of advanced pancreatic cancer and are increasingly used due to improved morbidity and complication rates compared to surgical management. In this review, we highlight various ERCP-guided diagnostic and therapeutic interventions for the management of pancreatic cancer. Copyright (c)The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.