TY  - BOOK
AU  - Howard, Barbara V
TI  - Relationship between diabetes risk and admixture in postmenopausal African-American and Hispanic-American women
SN  - 0012-186X
KW  - *African Continental Ancestry Group/sn [Statistics & Numerical Data]
KW  - *Diabetes Mellitus, Type 2/eh [Ethnology]
KW  - *Hispanic Americans/sn [Statistics & Numerical Data]
KW  - *Postmenopause
KW  - Adiposity/ge [Genetics]
KW  - African Continental Ancestry Group/ge [Genetics]
KW  - Aged
KW  - Diabetes Mellitus, Type 2/ge [Genetics]
KW  - European Continental Ancestry Group/ge [Genetics]
KW  - European Continental Ancestry Group/sn [Statistics & Numerical Data]
KW  - Female
KW  - Hispanic Americans/ge [Genetics]
KW  - Humans
KW  - Middle Aged
KW  - Risk
KW  - Social Class
KW  - MedStar Health Research Institute
KW  - Journal Article
KW  - Research Support, N.I.H., Extramural
N2  - AIMS/HYPOTHESIS: Type 2 diabetes is more prevalent in African-Americans (AFAs) and Hispanic-Americans (HAs) than in European-Americans. We assessed whether continental admixture was correlated with diabetes risk in these high-risk groups; CONCLUSIONS/INTERPRETATION: In AFAs, admixture, SES and BMI/WHR each independently contribute to diabetes risk after accounting for each of the other factors; in HAs, admixture, SES and BMI each independently contribute to diabetes risk after accounting for each of the other factors, whereas admixture is not significantly associated with diabetes risk after accounting for SES and WHR. The findings emphasise the importance of considering both genetic and environmental causes in the aetiology of type 2 diabetes; METHODS: We estimated the proportion of sub-Saharan African (AFR), Amerindian (AMI) and European admixture using 92 ancestry-informative marker genotypes in 16,476 AFA and HA women from the Women's Health Initiative. Cox regression models were used to examine the association between admixture and diabetes risk, with and without accounting for socioeconomic status (SES) and adiposity measurements; RESULTS: AFR admixture was significantly associated with diabetes risk in AFA women when adjusting for entry age, neighbourhood SES and BMI or waist/hip ratio (WHR) (all p < 0.0001). In HA women, AMI admixture had significant associations with diabetes risk that remained significant after adjustment for SES and BMI (all p < 0.0005). In both AFAs and HAs, SES showed significant negative associations while BMI or WHR had significant positive associations with diabetes risk, with and without adjustment for genetic admixture
UR  - http://dx.doi.org/10.1007/s00125-012-2486-4
ER  -