Molecule 16673-34-0: a new tool in our arsenal against inflammation.

Available online from MWHC library: 1996 - present

The NLRP3 inflammasome has been shown to modulate IL-1B and IL-18 production, both key molecular regulators of inflammation. This editorial discusses a new molecule 16673-34-0 that inhibits the NLRP3 inflammasome and decreases caspase 1 production following ischemia reperfusion or acute peritonitis in mice.


English

0160-2446


*Anti-Inflammatory Agents, Non-Steroidal/tu [Therapeutic Use]
*Benzamides/tu [Therapeutic Use]
*Carrier Proteins/ai [Antagonists & Inhibitors]
*Inflammasomes/ai [Antagonists & Inhibitors]
*Myocardial Reperfusion Injury/dt [Drug Therapy]
*Sulfonamides/tu [Therapeutic Use]
Animals
Benzamides/cs [Chemical Synthesis]
Blood Glucose/me [Metabolism]
Cell Line
Macrophages/de [Drug Effects]
Male
Mice
Peritonitis/ci [Chemically Induced]
Peritonitis/pc [Prevention & Control]
Sulfonamides/cs [Chemical Synthesis]


MedStar Heart & Vascular Institute


Journal Article