TY  - BOOK
AU  - Chen, Fang
AU  - Fatemi, Omid
AU  - Gai, Jiaxiang
AU  - Huffman, Christopher
AU  - Pichard, Augusto D
AU  - Satler, Lowell F
AU  - Suddath, William
AU  - Torguson, Rebecca
AU  - Waksman, Ron
TI  - Comparison of Bleeding Outcomes After Percutaneous Coronary Intervention in Patients With Versus Without Aortic Stenosis
SN  - 1879-1913
KW  - *Aortic Valve Stenosis/co [Complications]
KW  - *Coronary Artery Disease/su [Surgery]
KW  - *Percutaneous Coronary Intervention/ae [Adverse Effects]
KW  - *Postoperative Hemorrhage/ep [Epidemiology]
KW  - Age Factors
KW  - Aged
KW  - Coronary Artery Disease/co [Complications]
KW  - District of Columbia/ep [Epidemiology]
KW  - Female
KW  - Follow-Up Studies
KW  - Humans
KW  - Incidence
KW  - Male
KW  - Postoperative Hemorrhage/et [Etiology]
KW  - Retrospective Studies
KW  - Risk Factors
KW  - Sex Factors
KW  - MedStar Heart & Vascular Institute
KW  - Journal Article
KW  - Randomized Controlled Trial
N1  - Available online from MWHC library: 1995 - present, Available in print through MWHC library: 1999 - 2006
N2  - Aortic stenosis (AS) is associated with an increased risk of bleeding, but little is known about the risk of bleeding during percutaneous coronary intervention (PCI) in patients with AS. In the era of transcutaneous aortic valve implantation, understanding the bleeding risks associated with AS is critical. This retrospective study included 7,926 patients who underwent PCI from 2004 to 2013. Patients were categorized according to the presence of significant AS: moderate or severe AS (n = 354) and mild or no AS (n = 7,572). The National Cardiovascular Data Registry (NCDR) definition of a bleeding event (transfusion, prolonged hospital stay, or decrease in hemoglobin >3.0 mg/dl) was used as the primary outcome, and the NCDR PCI Bleeding Risk Score was used to control for the underlying risk of bleeding because of baseline characteristics. Patients with AS had significantly higher NCDR PCI Bleeding Risk Scores and higher rates of bleeding events. Logistic regression showed that the NCDR PCI Bleeding Risk Score did predict bleeding outcomes. There was not, however, an independent association between AS and bleeding outcomes. The addition of AS to the risk score using net reclassification improvement did not enhance the model's ability to predict bleeding (p = 0.71). These data suggest that the NCDR PCI Bleeding Risk Score appropriately adjusts for bleeding risks in patients with AS. In conclusion, although patients with AS are more likely to have bleeding complications after PCI, the increased risk of bleeding is driven by the patients' baseline co-morbidities rather than their AS. Copyright � 2015 Elsevier Inc. All rights reserved
UR  - http://dx.doi.org/10.1016/j.amjcard.2015.07.021
ER  -