TY  - BOOK
AU  - Sugarbaker, Paul H
TI  - Cytoreductive surgery plus hyperthermic perioperative chemotherapy to treat peritoneal metastases from colorectal cancer: standard of care or an experimental approach?
SN  - 1470-2045
PY  - 2012///
KW  - *Antineoplastic Combined Chemotherapy Protocols/st [Standards]
KW  - *Carcinoma/sc [Secondary]
KW  - *Carcinoma/th [Therapy]
KW  - *Colorectal Neoplasms/pa [Pathology]
KW  - *Hypothermia, Induced/st [Standards]
KW  - *Peritoneal Neoplasms/sc [Secondary]
KW  - *Peritoneal Neoplasms/th [Therapy]
KW  - *Peritoneum/su [Surgery]
KW  - *Standard of Care/st [Standards]
KW  - Antineoplastic Combined Chemotherapy Protocols/ae [Adverse Effects]
KW  - Carcinoma/mo [Mortality]
KW  - Chemotherapy, Adjuvant/st [Standards]
KW  - Colorectal Neoplasms/mo [Mortality]
KW  - Evidence-Based Medicine/st [Standards]
KW  - Humans
KW  - Hypothermia, Induced/ae [Adverse Effects]
KW  - Patient Selection
KW  - Perioperative Care/st [Standards]
KW  - Peritoneal Neoplasms/mo [Mortality]
KW  - Peritoneum/pa [Pathology]
KW  - Practice Guidelines as Topic
KW  - Risk Assessment
KW  - Risk Factors
KW  - Treatment Outcome
KW  - MedStar Washington Hospital Center
KW  - Surgery/General Surgery
KW  - Journal Article
N1  - Available online from MWHC library: 2001 - present
N2  - Peritoneal carcinomatosis is a common presentation in patients with metastatic colorectal cancer and the overall survival is poor. In most patients, the disease remains limited to the peritoneal cavity. Therefore, investigators have applied cytoreductive surgery and hyperthermic perioperative chemotherapy as the standard approach for selected patients with peritoneal metastases from colorectal cancer. Overall, very promising long-term survival has been shown in a subset of patients with a limited extent of peritoneal disease before treatment. Whether randomised, controlled trials are needed to definitively show the magnitude of benefit, if any, of this approach is an important question. This Debate outlines the arguments on each side of this issue. Copyright  2012 Elsevier Ltd. All rights reserved
UR  - http://dx.doi.org/10.1016/S1470-2045(12)70210-3
ER  -