Acute Presentation of Primary CNS Lymphoma Mimicking Toxoplasma in HIV Infection. 

 -  2023 
<br/><br/> Primary CNS lymphoma (PCNSL) accounts for up to 15% of non-Hodgkin lymphomas in HIV patients and is the second most common cause of space-occupying brain lesions in HIV patients after CNS toxoplasmosis. Differentiation of PCNL and CNS toxoplasmosis is crucial as PCNL carries a poor prognosis with survival time of 2-4 months without treatment but can be improved with prompt initiation of chemotherapy. These two entities often present clinically in a similar manner, and conventional imaging can also be a diagnostic challenge due to overlapping imaging characteristics. Thus, definitive diagnosis of PCNSL relies on histopathologic confirmation. Here, we present a case of intracranial lesion that presented acutely in the context of headache and left sided body weakness and was found to have PCNSL. Copyright © 2023 Greater Baltimore Medical Center. 
<br/><br/><br/>English 
<br/><br/><label>ISSN: </label>2000-9666 
<br/><br/><label>Standard No.: </label>jchim-13-06-017 [pii] PMC11000848 [pmc] 
<br/><br/><label>Subjects--Topical Terms: </label>--Automated
<br/><br/><label>Subjects--Geographic Terms: </label><br/>MedStar Franklin Square Medical Center<br/>MedStar Union Memorial Hospital
<br/><br/><label>Index Terms--Occupation: </label><br/>Internal Medicine Residency
<br/><br/><label>Index Terms--Function: </label><br/>Case Reports