TY - BOOK AU - Acharya, Indira AU - Bhansali, Deepty AU - DeBoer, Scott R TI - Acute Presentation of Primary CNS Lymphoma Mimicking Toxoplasma in HIV Infection SN - 2000-9666 PY - 2023/// KW - Automated KW - MedStar Franklin Square Medical Center KW - MedStar Union Memorial Hospital KW - Internal Medicine Residency KW - Case Reports N2 - Primary CNS lymphoma (PCNSL) accounts for up to 15% of non-Hodgkin lymphomas in HIV patients and is the second most common cause of space-occupying brain lesions in HIV patients after CNS toxoplasmosis. Differentiation of PCNL and CNS toxoplasmosis is crucial as PCNL carries a poor prognosis with survival time of 2-4 months without treatment but can be improved with prompt initiation of chemotherapy. These two entities often present clinically in a similar manner, and conventional imaging can also be a diagnostic challenge due to overlapping imaging characteristics. Thus, definitive diagnosis of PCNSL relies on histopathologic confirmation. Here, we present a case of intracranial lesion that presented acutely in the context of headache and left sided body weakness and was found to have PCNSL. Copyright © 2023 Greater Baltimore Medical Center UR - https://dx.doi.org/10.55729/2000-9666.1251 ER -