TY - BOOK AU - Bilalaga, Mariah Malak AU - Iding, Jeffrey AU - Sankineni, Abhinav AU - Vasireddy, Ramya TI - Challenges in Diagnosis: Primary Hepatic Lymphoma Presenting as a Space-Occupying Liver Lesion SN - 2326-3253 PY - 2024/// KW - Automated KW - MedStar Franklin Square Medical Center KW - MedStar Union Memorial Hospital KW - Gastroenterology KW - Internal Medicine Residency KW - Pathology KW - Case Reports KW - Journal Article N2 - Non-Hodgkin lymphoma is a heterogeneous group of lymphoid neoplasms, the incidence of which has increased over the past 3 decades. Primary non-Hodgkin lymphoma of the liver is a very rare malignancy. We outline a case describing primary hepatic lymphoma in an 85-year-old woman with a history of breast cancer who presented with generalized weakness and nonspecific symptoms. The patient had normal liver function, serum alpha fetoprotein level, and hemoglobin. A computed tomography scan of the chest, abdomen, and pelvis showed numerous low-attenuation lesions scattered throughout the liver. This case underscores the importance of including primary hepatic lymphoma as a differential diagnosis for space-occupying liver lesions, especially in the setting of normal alpha fetoprotein level. Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology UR - https://dx.doi.org/10.14309/crj.0000000000001443 ER -