Relationship between 25-hydroxy Vitamin D level and surgical site infection in spine surgery. 

 -  2024 
<br/><br/> Background: 25-hydroxy Vitamin D (25[OH]D) level has been shown to have antimicrobial and wound healing effects in animal models. Low preoperative 25(OH)D has been shown to correlate with surgical site infection (SSI) in thoracolumbar spine surgery.  Conclusion: SSI rates following thoracolumbar spine surgery were not affected by preoperative 25(OH)D levels. Copyright: © 2024 Surgical Neurology International.  Methods: This study involved 545 patients undergoing thoracolumbar spine surgery from 2012 to 2019 at an academic medical center. We evaluated the serum 25(OH)D level (i.e., adequate level = level 30-60 ng/dL), along with SSI, body mass index, and smoking status. Statistical analysis was done using bivariate analysis with Fisher's exact, Wilcoxon rank-sum test and multivarible logisitic regression analyses.  Results: We included 545 patients in the study, and there were no statistical differences in the average preoperative 25(OH)D between SSI and non-SSI groups. The average 25(OH)D in the non-SSI group was 31.6 ng/dL +/- 13.6, and the SSI group was 35.7 ng/dL +/- 20.2 (P = 0.63). 
<br/><br/><br/>English 
<br/><br/><label>ISSN: </label>2152-7806 
<br/><br/><label>Standard No.: </label>10.25259/SNI_135_2024 [pii] PMC11152506 [pmc] 
<br/><br/><label>Subjects--Topical Terms: </label>--Automated
<br/><br/><label>Subjects--Geographic Terms: </label><br/>MedStar Washington Hospital Center
<br/><br/><label>Index Terms--Occupation: </label><br/>Orthopedics
<br/><br/><label>Index Terms--Function: </label><br/>Journal Article