TY - BOOK AU - Rayes, Danny AU - Swett, Michael TI - Chagas Disease: Epidemiology, Diagnosis, and Treatment. [Review] SN - 1523-3782 PY - 2024/// KW - IN PROCESS -- NOT YET INDEXED KW - Internal Medicine Residency KW - MedStar Georgetown University Hospital/MedStar Washington Hospital Center KW - Journal Article KW - Review N2 - FUTURE RESEARCH: Use of antiparasitics during chronic chagas disease should be further explored. Additionally, future research identifying other markers of infection would be valuable to defining cure from infection. Copyright © 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature; PURPOSE OF REVIEW: This review seeks to describe the updates in the literature - particularly with regards to the epidemiology and diagnosis of Chagas disease. Additionally, this paper describes updates to the antiparasitic treatment for Chagas disease; RECENT FINDINGS: With regards to changing epidemiology, autochthonous cases are being found within the USA in addition to Latin America. Additionally, there appears to be more intermixing of discrete typing units-meaning, they are not confined to specific geographic regions. Screening for Chagas disease is recommended in persons who lived in areas with endemic Chagas, persons wtih family member diagnosed with Chagas Disease, persons who have lived in homes of natural material in Latin America, and persons with history of kissing bug bites. Treatment for the parasitic infection remains limited to benznidazole and nifurtimox, and the role of these treatments in Chagas cardiomyopathy has not yet been definitively defined. Finally, indications for and management of heart transplant in the setting of Chagas disease are discussed UR - https://dx.doi.org/10.1007/s11886-024-02113-7 ER -