TY  - BOOK
AU  - Howard, Barbara V
AU  - Iglesia, Cheryl B
AU  - Park, Amy J
AU  - Shara, Nawar M
AU  - Sokol, Andrew I
TI  - Effects of bilateral salpingo-oophorectomy at the time of hysterectomy on pelvic organ prolapse: results from the Women's Health Initiative trial
SN  - 1072-3714
PY  - 2015///
KW  - *Hysterectomy/ae [Adverse Effects]
KW  - *Ovariectomy/ae [Adverse Effects]
KW  - *Pelvic Organ Prolapse/ep [Epidemiology]
KW  - *Salpingectomy/ae [Adverse Effects]
KW  - *Women's Health
KW  - Age Factors
KW  - Aged
KW  - Body Mass Index
KW  - Continental Population Groups
KW  - Cystocele/ep [Epidemiology]
KW  - Estrogen Replacement Therapy
KW  - Female
KW  - Humans
KW  - Middle Aged
KW  - Odds Ratio
KW  - Parity
KW  - Pregnancy
KW  - Randomized Controlled Trials as Topic
KW  - Rectocele/ep [Epidemiology]
KW  - Retrospective Studies
KW  - Risk Factors
KW  - Waist-Hip Ratio
KW  - MedStar Health Research Institute
KW  - MedStar Washington Hospital Center
KW  - Obstetrics and Gynecology/Female Pelvic Medicine and Reconstructive Surgery
KW  - Journal Article
N1  - Available online from MWHC library: November 2000 - present
N2  - CONCLUSIONS: BSO at the time of hysterectomy is not associated with increased risk of cystocele or rectocele. BSO and no subsequent HT may even have a protective effect against cystocele or rectocele; METHODS: A retrospective analysis of the Women's Health Initiative estrogen-alone trial was performed. Women who retained their ovaries were compared with women who had BSO at the time of hysterectomy for the presence of cystocele or rectocele at entry into the study. Based on BSO and hormone therapy (HT) status, participants were categorized into groups. We hypothesized that BSO and prolonged hypoestrogenemia may be associated with an increased risk of prolapse. Univariate and multivariate analyses were used to determine the effects of BSO and HT status on cystocele and rectocele; OBJECTIVE: This study aims to estimate the effects of bilateral salpingo-oophorectomy (BSO) at the time of hysterectomy and estrogen therapy on vaginal prolapse; RESULTS: Of 10,739 participants in the estrogen-alone trial, 8,879 women were included in the analysis. Older age, higher parity, higher body mass index, higher waist-to-hip ratio, and non-African-American race/ethnicity were associated with increased odds of developing cystocele or rectocele. Women who retained their ovaries had higher rates of cystocele or rectocele at screening (39%) compared with all women who had BSO (31-36%; odds ratio, 1.18; 95% CI, 1.04-1.33). After controlling for multiple variables, our analysis showed that women who retained their ovaries had higher odds of developing cystocele or rectocele compared with women who had BSO and no subsequent HT (odds ratio, 1.23; 95% CI, 1.07-1.41). All other comparisons were nonsignificant
UR  - http://dx.doi.org/10.1097/GME.0000000000000375
ER  -