TY  - BOOK
AU  - Fernandez, Stephen J
AU  - Shara, Nawar M
TI  - High rate of microbleed formation following primary intracerebral hemorrhage
SN  - 1747-4930
PY  - 2015///
KW  - *Intracranial Hemorrhages/et [Etiology]
KW  - *Stroke/co [Complications]
KW  - Brain/pa [Pathology]
KW  - Female
KW  - Humans
KW  - Intracranial Hemorrhages/di [Diagnosis]
KW  - Intracranial Hemorrhages/eh [Ethnology]
KW  - Intracranial Hemorrhages/pa [Pathology]
KW  - Logistic Models
KW  - Longitudinal Studies
KW  - Magnetic Resonance Imaging
KW  - Male
KW  - Middle Aged
KW  - Multivariate Analysis
KW  - Prognosis
KW  - Prospective Studies
KW  - Risk Factors
KW  - Stroke/di [Diagnosis]
KW  - Stroke/eh [Ethnology]
KW  - Stroke/pa [Pathology]
KW  - Time Factors
KW  - United States/ep [Epidemiology]
KW  - MedStar Health Research Institute
KW  - MedStar Washington Hospital Center
KW  - MedStar Heart Institute
KW  - Journal Article
N2  - AIMS AND/OR HYPOTHESIS: To investigate the frequency and predictors of new microbleeds following intracerebral hemorrhage; BACKGROUND: We sought to investigate the frequency of microbleed development following intracerebral hemorrhage in a predominantly African-American population and to identify predictors of new microbleed formation; CONCLUSIONS: We found that one-third of intracerebral hemorrhage subjects in this cohort surviving one-year developed new microbleeds, which suggests a dynamic and rapidly progressive vasculopathy. Future studies are needed to examine the impact of new microbleed formation on patient outcomes.Copyright (c) 2015 World Stroke Organization; METHODS: The DECIPHER study was a prospective, longitudinal, magnetic resonance-based cohort study designed to evaluate racial/ethnic differences in risk factors for microbleeds and to evaluate the prognostic impact of microbleeds in this intracerebral hemorrhage population. We evaluated new microbleed formation in two time periods: from baseline to 30 days and from 30 days to year 1; RESULTS: Of 200 subjects enrolled in DECIPHER, 84 had magnetic resonance imaging at all required time points to meet criteria for this analysis. In the baseline to day 30 analysis, 11 (13.1%) had new microbleeds, compared with 25 (29.8%) in the day 30 to year 1 analysis. Logistic regression analysis demonstrated that baseline number of microbleeds [odds ratio 1.05 (95% confidence interval 1.01, 1.08), P=0.01] was associated with new microbleed formation at 30 days. A logistic regression model predicting new microbleed at one-year included baseline number of microbleeds [odds ratio 1.05 (1.00, 1.11), P=0.046], baseline age [odds ratio 1.05 (1.00, 1.10), P=0.04], and white matter disease score [odds ratio 1.18 (0.96, 1.45). P=0.115]. Overall, 28 of 84 (33.3%) intracerebral hemorrhage subjects formed new microbleeds at some point in the first year post-intracerebral hemorrhage
UR  - http://dx.doi.org/10.1111/ijs.12607
ER  -